AUTHOR=Geleta Tinsae Abeya , Deriba Berhanu Senbeta , Dirirsa Dejene Edosa TITLE=What Factors Encourage Young People to Engage in Substance Use? Substance Use and Associated Factors Among Youth in Southwest Ethiopia: A Community-Based Study JOURNAL=Frontiers in Public Health VOLUME=Volume 10 - 2022 YEAR=2022 URL=https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2022.796687 DOI=10.3389/fpubh.2022.796687 ISSN=2296-2565 ABSTRACT=Abstract Background: Substance use indicated the use of psychoactive substances such as alcohol, cigarettes, khat, and illegal drugs. The prevalence of substance use is different between countries from time to time. Currently, substance use is a common public health problem among Ethiopian youth mainly in the city of Jimma. The purpose of this study was to assess the magnitude of Cigarette smoking, alcohol drinking, khat chewing, and associated factors among youth in Jimma town. Methods: The study was carried out in Jimma town through a community-based cross-sectional survey, and 570 households participated in this study. Data were entered using Epi-data manager version 4.4.1 and exported to IBM SPSS version 21.0 for analysis. Logistic regression analyzes were used to identify factors associated with cigarettes, alcohol, and khat. Results: The current prevalence of cigarette use, alcohol use, and khat use was 16.0%, 30.6%, and 45.7%, respectively. Factors associated with current smoking use were substance use by siblings, subjective norm factors, and perceived benefits of substance use. Factors associated with current alcohol consumption were youth who highly perceived substance use as important. Factors associated with current Khat use were male, substance use by siblings, out-of-school youth, and subjective norms. Concussion: The study findings indicated that the prevalence of khat, alcohol, and cigarettes was high among the youth of the city of Jimma. To alleviate these factors, coordinated efforts from the youth, the government, and the community at large are needed. Keywords: Substance use, youth, Jimma, Ethiopia