AUTHOR=Amer Samar A. , Shah Jaffer , Abd-Ellatif Eman Elsayed , El Maghawry Hala A. TITLE=COVID-19 vaccine uptake among physicians during the second wave of COVID-19 pandemic: Attitude, intentions, and determinants: A cross-sectional study JOURNAL=Frontiers in Public Health VOLUME=Volume 10 - 2022 YEAR=2022 URL=https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2022.823217 DOI=10.3389/fpubh.2022.823217 ISSN=2296-2565 ABSTRACT=Background: Developed within a short period of time, the COVID-19 vaccine is not yet widely accepted among the public despite its availability, including to physicians, who are considered a vulnerable group. Methodology: A descriptive cross-sectional study selected 436 governmental physicians from different specializations, representing 4 random administrative regions in Egypt. The data was collected through a self-administrated online questionnaire and analyzed using suitable tests. Results: Out of the studied 436 physicians, 229 (52.2%) were ages (20-30, 284 (65.1%) were females, 270 (61.9%) were residents, 219 (50.2%) were married, 398 (91.3%) were non-smokers, and 263 (60.3%) were non-frontline care-givers. The majority of the physicians, 227 (52.1%) of them, hesitated to take the vaccine, 236 (54.1%) have not decided on the preferred type of vaccine, and 101 (23.2%) were neutrally confident in the Egyptian health care system. 302 (96.3%) have no history of drug or food hypersensitivity. There is no statistically significant (p<0.05) relationship between the physicians’ attitude toward COVID-19 vaccine uptake and the studied demographic variables. There is a statistically significant connection between all of the doctors’ intentions to get the COVID-19 vaccine and all of the four attitude domains that were looked at. Conclusion: The study concluded that a low level of willingness among Egyptian physicians to take the COVID-19 vaccine is a prevalent problem. COVID-19 vaccination hesitancy and non-acceptance were linked to negative attitudes about natural immunity, mistrust of vaccine benefits, and concerns about commercial profiteering.