AUTHOR=Qiu Haiyuan , Guo Rong , Zhang Yuanwen , Ying Jianghui , Yan Yazhou , Xiong Jiachao 

TITLE=A Bibliometric Analysis of the Hotspots Concerning Stem Cell Extracellular Vesicles for Diabetes in the Last 5 Years

JOURNAL=Frontiers in Public Health

VOLUME=Volume 10 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2022.868440

DOI=10.3389/fpubh.2022.868440

ISSN=2296-2565

ABSTRACT=Background: Diabetes mellitus (DM) is a metabolic disease that endanger human health, and its prevalence is exploding and younger. Extracellular vesicles derived from stem cells (SC-EVs) have similar repair function to stem cells and no risk of tumor formation, which were widely used in the repair of DM and its complications. We aim to map hot trends in SC-EVs for DM treatment and providing directions for future research.
Methods: We screened all relevant publications on SC-EVs for DM from Web of Science during 2017–2021, and the research trends in this field were analyzed by VOSviewer and CiteSpace.
Results: A total of 255 articles were related to SC-EVs for DM according to the search strategy were screened out. China (122 publications and 2759 citations) was the most productive country, followed by the United States (50 publications and 1167 citations) and Italy (16 publications and 366 citations). The top five institutions with the most publications were located in Italy and China, and Turin university was the most productive institution. The journals Stem Cell Research and Therapy and International Journal of Molecular Sciences were publishing the most studies on SC-EVs for DM. ASHOK KUMAR published the majority of articles in this field, while QING LI was cited most frequently. Cluster analysis indicated that the current research trend is more focused on the repair mechanism and clinical translation of exosomes and their related preparations in promoting DM and its complications.
Conclusion: A comprehensive summary and analysis of the global research trends of SC-EVs used in DM and its complications was performed in this study. In the past 5 years, relevant high-quality publications in this field have increased significantly, and SC-EVs s have a good development prospect in the treatment of DM and its complications.