AUTHOR=Ren Yanli , Tong Enyu , Di Chunhong , Zhang Yunheng , Xu Liangwen , Tan Xiaohua , Yang Lei 

TITLE=Association Between ABCA1 Gene Polymorphisms and the Risk of Hypertension in the Chinese Han Population

JOURNAL=Frontiers in Public Health

VOLUME=Volume 10 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2022.878610

DOI=10.3389/fpubh.2022.878610

ISSN=2296-2565

ABSTRACT=Background: Hypertension is rising as a major public health burden around the world. This study explored the association of single-nucleotide polymorphisms (SNPs) in the ATP Binding Cassette Subfamily A1 (ABCA1) gene and hypertension among Chinese Han adults. Method: A total of 2296 Han Chinese in southeast China were recruited for this study. We collected medical reports, lifestyle details, and blood samples from individuals. The polymerase chain reaction-ligase detection reaction (PCR-LDR) method was used to detect the genotypes of these SNPs in the ABCA1 gene. Results: After adjusting some covariates, the additive and recessive models of the rs2472510 and rs2515614 were significantly associated with hypertension. The haplotypes TCTA (rs2297406-rs2472433-rs2472510-rs2515614.) were associated with high SBP, and the haplotype CCTA, TCTA and TTTA were associated with high DBP. Conclusion: The results of the relationship between the polymorphisms of rs2297406, rs2472433, rs2472510 and rs2515614 in ABCA1 and hypertension in southeastern China would provide a theoretical basis for genetic screening and disease prevention.