AUTHOR=Shah Gulzar H. , Etheredge Gina D. , Maluantesa Lievain , Waterfield Kristie C. , Ikhile Osaremhen , Engetele Elodie , Mulenga Astrid , Tabala Alice , Bossiky Bernard TITLE=Socioeconomic status and other factors associated with HIV status among OVC in Democratic Republic of Congo (DRC) JOURNAL=Frontiers in Public Health VOLUME=Volume 10 - 2022 YEAR=2022 URL=https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2022.912787 DOI=10.3389/fpubh.2022.912787 ISSN=2296-2565 ABSTRACT=Background: Orphans and vulnerable children (OVC) are a high-risk group for HIV infection, particularly in Sub-Saharan Africa. Purpose: This study aims to portray the socioeconomic profile of OVC, as well as examine the association of household and parent/guardian characteristics with the HIV status of OVC. Methods: For this quantitative retrospective study, we obtained data from ICAP/DRC for a total of 1,624 OVC from households enrolled for social, financial, and clinical services between January 2017, and April 2020, in two provinces of Democratic Republic of Congo, Haut-Katanga and Kinshasa. We computed descriptive statistics for OVC and their parents’ or guardians’ characteristics. We used the chi-square test to determine bivariate associations of the predictor variables with the dichotomous dependent variable, HIV positivity status. To analyze the association between these independent variables and the dichotomous dependent variable HIV status after controlling for other covariates, we performed Firth’s Logistic Regression. Results: Of the OVC included in this study 18% were orphans and 10.9% were HIV-positive. The Chi-square analysis showed that among parents/guardians that were HIV-positive, a significantly lower proportion (11.7%) was HIV-positive rather than HIV-negative (26.3%). In contrast, for parents/guardians with HIV-negative status, 9.0% of OVC were HIV-negative and 11.7% of OVC were OVC-positive. The Firth’s Logistic Regression also showed adjusted odds of HIV-positive status were significantly lower for OVC with parents/guardians having HIV-positive status themselves (AOR, 0.335; 95% CI, 0.171-0.656) compared with HIV-negative parents/guardians. The adjusted odds of HIV-positive status were significantly lower for OVC with monthly income < $30 (AOR, 0.421; 95% CI, 0.202-0.877) compared with OVC with monthly income > $30. Conclusions: Our results suggest that with an exception of a few household and parent/guardian characteristics, the risk of HIV-positive status is uniform across all groups of OVC within this study, which is consistent with the existing body of evidence showing that OVC are in general vulnerable to HIV infection. With a notable proportion of children who are single or double orphans in DRC, HIV-positive OVC constitute a high-risk group that merits customized HIV services. The findings of this study provide data-driven scientific evidence to guide such customization of HIV services.