AUTHOR=Macrì Monica , Festa Felice TITLE=Three-dimensional evaluation using CBCT of the mandibular asymmetry and the compensation mechanism in a growing patient: A case report JOURNAL=Frontiers in Public Health VOLUME=Volume 10 - 2022 YEAR=2022 URL=https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2022.921413 DOI=10.3389/fpubh.2022.921413 ISSN=2296-2565 ABSTRACT=Background This case report aims to evaluate the development and the compensation mechanisms of the mandibular asymmetry in a growing male patient, using Cone Beam Computed Tomography (CBCT). In this case, the menton was deviated on the right, an extremely rare condition, which may be the consequence of a disorder in the mandibular growth. Case presentation The young male patient was treated with Rapid Palatal Expander (RPE) and Fränkel Functional Regulator III (FR-3). The initial CBCT was acquired at the beginning of therapy when the patient was 8 years old (y.o), the final CBCT was acquired at the end of the treatment when the patient was 12 y.o. The patient’s CBCT was performed with the head oriented according to the Natural Head Position (NHP); the NHP is a physiological and reproducible posture defined for morphological analysis. The 3D image of the cranium was oriented in the Dolphin software according to NHP posture; the cephalometric measurements were performed in frontal, laterolateral right and left, posteroanterior and submentovertex views in the software as mentioned above. The therapy lasted 3.8 years and ended with a significant regression of the mandibular asymmetry from moderate grade (4.2 mm) to slight grade (1.3 mm). Conclusion The left hemi-mandible has grown more than the right side, in accordance with the literature, which affirms that in case of deviation of the menton greater than 4 mm, the bone volume increases on the non-deviated side.