AUTHOR=Wang Junjun , Ma Tao , Ding Songning , Xu Ke , Zhang Min , Zhang Zhong , Dai Qigang , Tao Shilong , Wang Hengxue , Cheng Xiaoqing , He Min , Du Xuefei , Feng Zhi , Yang Huafeng , Wang Rong , Xie Chaoyong , Xu Yuanyuan , Liu Li , Chen Xupeng , Li Chen , Wu Wen , Ye Sheng , Yang Sheng , Fan Huafeng , Zhou Nan , Ding Jie 

TITLE=Dynamic characteristics of a COVID-19 outbreak in Nanjing, Jiangsu province, China

JOURNAL=Frontiers in Public Health

VOLUME=10

YEAR=2022

URL=https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2022.933075

DOI=10.3389/fpubh.2022.933075

ISSN=2296-2565

ABSTRACT=<sec><title>Objectives</title><p>Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lineage B.1.617.2 (also named the Delta variant) was declared as a variant of concern by the World Health Organization (WHO). This study aimed to describe the outbreak that occurred in Nanjing city triggered by the Delta variant through the epidemiological parameters and to understand the evolving epidemiology of the Delta variant.</p></sec><sec><title>Methods</title><p>We collected the data of all COVID-19 cases during the outbreak from 20 July 2021 to 24 August 2021 and estimated the distribution of serial interval, basic and time-dependent reproduction numbers (R<sub>0</sub> and R<sub>t</sub>), and household secondary attack rate (SAR). We also analyzed the cycle threshold (Ct) values of infections.</p></sec><sec><title>Results</title><p>A total of 235 cases have been confirmed. The mean value of serial interval was estimated to be 4.79 days with the Weibull distribution. The R<sub>0</sub> was 3.73 [95% confidence interval (CI), 2.66–5.15] as estimated by the exponential growth (EG) method. The R<sub>t</sub> decreased from 4.36 on 20 July 2021 to below 1 on 1 August 2021 as estimated by the Bayesian approach. We estimated the household SAR as 27.35% (95% CI, 22.04–33.39%), and the median Ct value of open reading frame 1ab (ORF1ab) genes and nucleocapsid protein (N) genes as 25.25 [interquartile range (IQR), 20.53–29.50] and 23.85 (IQR, 18.70–28.70), respectively.</p></sec><sec><title>Conclusions</title><p>The Delta variant is more aggressive and transmissible than the original virus types, so continuous non-pharmaceutical interventions are still needed.</p></sec>