AUTHOR=Schiltz Nicholas K. 

TITLE=Prevalence of multimorbidity combinations and their association with medical costs and poor health: A population-based study of U.S. adults

JOURNAL=Frontiers in Public Health

VOLUME=Volume 10 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2022.953886

DOI=10.3389/fpubh.2022.953886

ISSN=2296-2565

ABSTRACT=BACKGROUND: Multimorbidity is common, but the prevalence and burden of the specific combinations of coexisting disease has not been systematically examined in the general U.S. adult population. 
OBJECTIVE: To identify and estimate the burden of highly prevalent combinations of chronic conditions that are treated among one million or more U.S. adults.
METHODS: Cross-sectional analysis of U.S. households in the Medical Expenditure Panel Survey (MEPS), 2016–2019, a large nationally-representative sample of the community-dwelling population. Association rule mining was used to identify the most common combinations of 20 chronic conditions that have high relevance, impact, and prevalence in primary care. The main measures and outcomes were annual treated prevalence, total medical expenditures, and perceived poor health. Logistic regression models with poor health as the outcome and each multimorbidity combination as the exposure were used to calculate adjusted odds ratios and 95% confidence intervals.
RESULTS: Frequent pattern mining yielded 223 unique combinations of chronic disease, including 74 two-way, 115 three-way, and 34 four-way combinations that are treated in one million or more U.S. adults. Hypertension-hyperlipidemia was the most common two-way combination occurring in 30.8 million adults. The combination of diabetes-arthritis-cardiovascular disease was associated with the highest median annual medical expenditures ($23,850, interquartile range: $11,593–$44,616), and the combination of diabetes-arthritis-asthma/COPD had the highest age-race-sex adjusted odds ratio (6.9, 95%CI: 5.4–8.8) of poor self-rated health.
CONCLUSION: This study demonstrates that many multimorbidity combinations are highly prevalent and burdensome among U.S. adults. These combinations could be prioritized for evidence-based research on optimal prevention and treatment strategies.