AUTHOR=Tao Zhang , Zhu Hua , Zhang Jiateng , Huang Zhiming , Xiang Ze , Hong Tu 

TITLE=Recent advances of eosinophils and its correlated diseases

JOURNAL=Frontiers in Public Health

VOLUME=Volume 10 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2022.954721

DOI=10.3389/fpubh.2022.954721

ISSN=2296-2565

ABSTRACT=Human eosinophils exhibit unique multi-leaf nuclear morphology, which are filled with cytoplasmic granules that contain cytotoxicity and immune regulatory proteins. In recent years, it has been discovered that the eosinophils have the regulatory functions of innate and adaptive immunity and play an important role in asthma, chronic obstructive pulmonary diseases, acute respiratory distress syndrome and malignant tumors. In this review, we start from the perspective of eosinophil physiological function. Its developmental-related molecular mechanism, granule protein composition, and pathophysiological functions are also comprehensively elucidated. To conclude, the guiding significance of future disease treatment is proposed based on the recent updated understandings into the cell functions of eosinophils.