AUTHOR=Marzo Roy R. , Shrestha Rajeev , Sapkota Binaya , Acharya Swosti , Shrestha Nita , Pokharel Mandip , Ahmad Absar , Patalinghug Mark E. , Rahman Farzana , Salim Zahir R. , Bicer Burcu K. , Lotfizadeh Masoud , Wegdan Baniissa , Moura Villela Edlaine F. de , Jermsittiparsert Kittisak , Hamza Nouran A. , Saleeb Marina R. , Respati Titik , Fitriyana Susan , Bhattacharya Sudip , Heidler Petra , Qalati Sikandar A. , Aung Yadanar , Abid Khadijah , Abeje Tayachew A. , Pokhrel Ashmita , Roien Rohullah , King Isabel , Su Tin Tin TITLE=Perception towards vaccine effectiveness in controlling COVID-19 spread in rural and urban communities: A global survey JOURNAL=Frontiers in Public Health VOLUME=Volume 10 - 2022 YEAR=2022 URL=https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2022.958668 DOI=10.3389/fpubh.2022.958668 ISSN=2296-2565 ABSTRACT=Abstract Introduction Several studies exhibited varying reports of hesitancy and acceptance of covid-19 vaccines. As this fluctuated with evidence generation, the present study explored the predictors of covid vaccine hesitancy in rural and urban communities among various countries. Methods A cross-sectional study was conducted from April to August 2021 using convenience sampling among people from different countries approved by the Asia Metropolitan University Medical Research and Ethics. We adapted the questionnaire from the World Health Organization’s (WHO) survey tool and guidance on covid-19. The logistic regression models were performed to show the predictors for vaccine hesitancy. Results A total of 5,673 participants responded to the study. Overall, 64% of participants agreed that the vaccine effectively controlled viral spread, 26% agreed that there was no need for vaccination for post-covid-19 patients, and 23% agreed that there was no need for vaccination if others were vaccinated. Conclusion People's perceptions and attitudes toward vaccine acceptance have fluctuated with the information flow in various social media and the severity of covid cases. Therefore, it is important that the current scenario of peoples’ perception toward vaccine acceptance and determinants affecting the same be explored to promote the vaccination approach against Covid prevention and transmission effectively.