AUTHOR=Yeh Kenneth B. , Parekh Falgunee K. , Mombo Illich , Leimer Joseph , Hewson Roger , Olinger Gene , Fair Jeanne M. , Sun Yijun , Hay John TITLE=Climate change and infectious disease: A prologue on multidisciplinary cooperation and predictive analytics JOURNAL=Frontiers in Public Health VOLUME=Volume 11 - 2023 YEAR=2023 URL=https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2023.1018293 DOI=10.3389/fpubh.2023.1018293 ISSN=2296-2565 ABSTRACT=Climate change impacts global ecosystems at the interface of infectious disease agents and hosts and vectors for animals, humans, and plants. The climate is changing, and the impacts are complex, with multifaceted effects. In addition to connecting climate change and infectious diseases, we aim to draw attention to work being done across multiple disciplines that facilitate our ability to study infectious diseases in all life forms. The world’s experience with COVID-19 has revealed many gaps in our past approaches to anticipating emerging infectious diseases. Most approaches to predicting outbreaks and identifying emerging microbes of major consequence have been with those causing high morbidity and mortality in humans and animals. These lagging indicators offer limited ability to prevent spillover and disease amplifications in new hosts. Leading indicators and novel approaches are more valuable and now feasible, with multidisciplinary approaches also within our grasp to provide links to disease predictions through holistic monitoring of micro and macro ecological changes. In this commentary, we describe target areas for infectious diseases and biosecurity as well as overarching themes for the roles of team science and predictive analytics. With a multidisciplinary cooperative approach using predictive analytic tools, we can enhance our ability to engage and resolve current and emerging problems.