AUTHOR=Mozaffari Sajjad , Heibati Behzad , Jaakkola Maritta S. , Lajunen Taina K. , Kalteh Safa , Alimoradi Hadi , Nazari Mahsa , Karimi Ali , Jaakkola Jouni J. K. TITLE=Effects of occupational exposures on respiratory health in steel factory workers JOURNAL=Frontiers in Public Health VOLUME=Volume 11 - 2023 YEAR=2023 URL=https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2023.1082874 DOI=10.3389/fpubh.2023.1082874 ISSN=2296-2565 ABSTRACT=Background: The steel factory work environment contains various chemical exposures that can affect indoor air quality and have impact on respiratory health of the workers. Aims: The objective of this study was to assess potential effects of occupational exposures in steel factory workers in Iran on the respiratory symptoms’ occurrence and the lung function levels. Method: This study is a cross-sectional study of 133 men working in a steel factory forming the exposed group and 133 men office workers forming the reference group from a steel company in Iran. The participants filled in a questionnaire and underwent spirometry. Work history was used both as dichotomous (exposed/reference) and quantitative measure of exposure, measured as duration of exposure in the specified work (in years) for the exposed group and zero for the reference group. Prevalence ratio (PR) was the measure of effect expressing the risk of respiratory symptoms and the difference in means of lung function parameters. Results: Multiple linear regression and Poisson regression were used to adjust for confounding. In Poisson regression analyses, an increased prevalence ratio (PR) of all respiratory symptoms was observed in the exposed group. Lung function parameters were significantly reduced in the exposed group (p < 0.001). There was a dose–response relation between duration of occupational exposures and reduction in predicted value of FEV1/FVC level (0.177, 95% CI -0.198 to -0.156) in all models. Conclusion: The results of these analyses showed that occupational exposures in steel factory work increase the prevalence of respiratory symptoms and reduced lung function. Safety training and workplace conditions were found to need improvement. In addition, use of proper personal protective equipment is recommended.