AUTHOR=Roure Sílvia , Vallès Xavier , Sopena Nieves , Benítez Rosa Maria , Reynaga Esteban A. , Bracke Carmen , Loste Cora , Mateu Lourdes , Antuori Adrián , Baena Tania , Portela Germán , Llussà Judith , Flamarich Clara , Soldevila Laura , Tenesa Montserrat , Pérez Ricard , Plasencia Elsa , Bechini Jordi , Pedro-Botet Maria Lluïsa , Clotet Bonaventura , Vilaplana Cristina TITLE=Disseminated tuberculosis and diagnosis delay during the COVID-19 era in a Western European country: a case series analysis JOURNAL=Frontiers in Public Health VOLUME=Volume 11 - 2023 YEAR=2023 URL=https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2023.1175482 DOI=10.3389/fpubh.2023.1175482 ISSN=2296-2565 ABSTRACT=Background

Disseminated tuberculosis is frequently associated with delayed diagnosis and a poorer prognosis.

Objectives

To describe case series of disseminated TB and diagnosis delay in a low TB burden country during the COVID-19 period.

Methodology

We consecutively included all patients with of disseminated TB reported from 2019 to 2021 in the reference hospital of the Northern Crown of the Metropolitan Area of Barcelona. We collected socio-demographic information, clinical, laboratory and radiological findings.

Results

We included all 30 patients reported during the study period—5, 9, and 16 in 2019, 2020, and 2021 respectively—20 (66.7%) of whom were male and whose mean age was 41 years. Twenty-five (83.3%) were of non-EU origin. The most frequent system involvement was central nervous system (N = 8; 26.7%) followed by visceral (N = 7; 23.3%), gastro-intestinal (N = 6, 20.0%), musculoskeletal (N = 5; 16.7%), and pulmonary (N = 4; 13.3%). Hypoalbuminemia and anemia were highly prevalent (72 and 77%). The median of diagnostic delay was 6.5 months (IQR 1.8–30), which was higher among women (36.0 vs. 3.5 months; p = 0.002). Central nervous system involvement and pulmonary involvement were associated with diagnostic delay among women. We recorded 24 cured patients, two deaths, three patients with post-treatment sequelae, and one lost-to-follow up. We observed a clustering effect of patients in low-income neighborhoods (p < 0.001).

Conclusion

There was a substantial delay in the diagnosis of disseminated TB in our study region, which might impacted the prognosis with women affected more negatively. Our results suggest that an increase in the occurrence of disseminated TB set in motion by diagnosis delay may have been a secondary effect of the COVID-19 pandemic.