AUTHOR=Fu Guiqin , Cheng Haimin , Lu Qian , Liu Huayue , Zhang Xiaohui , Zhang Xingshan TITLE=The synergistic effect of high temperature and ozone on the number of deaths from circulatory system diseases in Shijiazhuang, China JOURNAL=Frontiers in Public Health VOLUME=Volume 11 - 2023 YEAR=2023 URL=https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2023.1266643 DOI=10.3389/fpubh.2023.1266643 ISSN=2296-2565 ABSTRACT=Urban ozone pollution in China is becoming increasingly serious. Climate warming, high temperature and ozone pollution all have important impacts on human health.However, the synergistic effects of high temperature and ozone pollution in summer on human health are rarely studied. China is at a critical stage of environmental pollution control. Assessing the health impact of high temperature and ozone exposure on the number of deaths from circulatory diseases is of great significance for formulating ozone-related prevention and control policies. This study uses daily data on deaths from circulatory system diseases in Shijiazhuang from June to August during the summer of 2013-2016, as well as concurrent meteorological data and concentration of O3 and PM2.5 pollution data. The generalized additive model (GAM) with Poisson distribution, smooth curve threshold effect, and saturation effect method is used to control for confounding effects. The study evaluates the impact of short-term exposure to temperature and ozone on deaths from circulatory system diseases and the synergistic effect after controlling for confounding factors. The results show that the impact of temperature and ozone on deaths from circulatory system diseases in Shijiazhuang is nonlinear, with a temperature threshold of 27.5°C and an ozone concentration threshold of 100 μg/m 3 . When O3 (ozone) is greater than or equal to 100μg/m 3 and T (temperature) is greater than or equal to 27.5°C, With the increase of temperature by 1℃, the total number of deaths from circulatory system diseases, men and women of different genders show the largest risk effect values, which are 6.8%, 4.6% and 9.3% respectively. It has a greater impact on women, and men have a lag effect of 2 to 3 days, but women did not notice the lag effect. In conclusion, high temperature and high ozone concentration have synergistic enhancement effect on circulatory system diseases. Prevention and scientific management strategies of circulatory system diseases in high temperature and high ozone environment should be strengthened.