AUTHOR=López-Cuevas Jonathan Ariel , Martínez-García Mireya , Hernández-Lemus Enrique , Anda-Jáuregui Guillermo de TITLE=Exploring disparities and novel insights into metabolic and cardiovascular comorbidities among COVID-19 patients in Mexico JOURNAL=Frontiers in Public Health VOLUME=Volume 11 - 2023 YEAR=2023 URL=https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2023.1270404 DOI=10.3389/fpubh.2023.1270404 ISSN=2296-2565 ABSTRACT=During the previous years, particularly at the beginning of the COVID-19 pandemic, the potential role of metabolic and cardiovascular comorbidities in the severity and lethality of SARS-CoV2 infection has been widely discussed, often describing ambiguous outcomes. Here we investigate the prevalence of metabolic and cardiovascular comorbidities among COVID-19 patients in Mexico. Using a retrospective observational study design, data was collected from official databases of COVID-19 patients admitted to public and private hospitals in Mexico City. Our study found a discordant prevalence of metabolic and cardiovascular comorbidities among COVID-19 patients, particularly obesity, hypertension, and diabetes. Discordance consists in geographic location-dependent over and under-representation phenomena, that is the prevalence of such comorbidities in COVID-19 patients was significantly over or under the reported value for the general population in each location. These findings highlight the importance of screening for metabolic and cardiovascular comorbidities in COVID-19 patients and suggest the need for tailored interventions for this population. The study also provides insights into the complex relationships between COVID-19 and metabolic and cardiovascular comorbidities, which may inform future research and clinical practice.