AUTHOR=Dessemon Juliette , Perol Olivia , Chauvel Cécile , Noelle Hugo , Coudon Thomas , Grassot Lény , Foray Nicolas , Belladame Elodie , Fayette Jérôme , Fournie Françoise , Swalduz Aurélie , Neidhart Eve-Marie , Saintigny Pierre , Tabutin Mayeul , Boussageon Maxime , Gomez Frédéric , Avrillon Virginie , Perol Maurice , Charbotel Barbara , Fervers Béatrice 

TITLE=Survival of bronchopulmonary cancers according to radon exposure

JOURNAL=Frontiers in Public Health

VOLUME=Volume 11 - 2023

YEAR=2024

URL=https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2023.1306455

DOI=10.3389/fpubh.2023.1306455

ISSN=2296-2565

ABSTRACT=Residential exposure is estimated to be responsible for nearly 10% of lung cancers in 2015 in France, making it the 2nd leading cause, after tobacco. The Auvergne-Rhône-Alpes region, in the southwest of France, is particularly affected by this exposure as 30% of the population lives in areas with medium or high radon potential. The aim of this study was to investigate the impact of radon exposure on the survival of lung cancer patients. In this single-centre study, patients with a histologically confirmed diagnosis of lung cancer, and newly managed, were prospectively included between 2014 and 2020. Univariate and multivariate survival analyses were carried out using a non-proportional risk survival model to consider variations in risk over time. A total of 1,477 patients were included in the analysis. In the multivariate analysis and after adjustment for covariates, radon exposure was not statistically associated with survival of bronchopulmonary cancers (HR=0.82 [0.54-1.23], HR=0.92 [0.72-1.18], HR=0.95 [0.76-1.19] at 1, 3 and 5 years respectively for patients residing in category 2 municipalities; HR=0.87 [0.66-1.16], HR=0.92 [0.76-1.10], HR=0.89 [0.75-1.06] at 1, 3 and 5 years respectively for patients residing in category 3 municipalities). Although radon exposure is known to increase the risk of lung cancer, in the present study no significant association was found between radon exposure and survival of bronchopulmonary cancers.