AUTHOR=Li Jintao , Yang Chao , Xiang Kui 

TITLE=Association between oxidative balance score and prostate specific antigen among older US adults

JOURNAL=Frontiers in Public Health

VOLUME=Volume 11 - 2023

YEAR=2024

URL=https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2023.1336657

DOI=10.3389/fpubh.2023.1336657

ISSN=2296-2565

ABSTRACT=Objective: Oxidative Balance Score (OBS) is an index affecting the oxidative stress of dietary and lifestyle exposures. We aimed to explore the association of OBS with prostate specific antigen (PSA) among older males.Methods A total of 5,136 samples were collected in this study to investigate the relationship between OBS and PSA from National Health and Nutrition Examination Survey. Logistic regression models and restricted cubic spline were used to assess the associations between OBS and PSA.Results: Compared with Q1 group, the odds ratios for the association between OBS and PSA were 1.005 (1.003, 1.009), 1.003 (1.001, 1.006), and 1.001 (0.978, 1.022) for Q2, Q3 and Q4, respectively. In the age-specific analyses, the association was significant among individuals aged equal and over 65 years old, the odds ratios for the association between OBS and PSA were 1.019 (1.005, 1.028), 1.028 (1.018, 1.039), and 1.038 (1.022, 1.049) for Q2, Q3 and Q4, respectively. But it was not significant among individuals aged below 65 years old, the odds ratios for the association between OBS and PSA were 1.026 (0.995, 1.026), 1.015 (0.985, 1.022), and 0.988 (0.978, 1.016) for Q2, Q3 and Q4, respectively. The restricted cubic splines also indicated a nonlinear relationship between OBS and PSA among individuals aged equal and over 65 years old (P overall =0.006, P nonlinear =0.021).Our findings provide evidence that OBS is positively associated with higher level of PSA among older adults. Further large-scale prospective cohort studies are needed to verify our findings.