AUTHOR=Asefa Lechisa , Lemma Hailu , Daba Chala , Dhengesu Degefa , Ibrahim Mommedgezali TITLE=COVID-19 vaccine acceptance and associated factors among health workers in West Guji zone, Southern Ethiopia: Cross-sectional study JOURNAL=Frontiers in Public Health VOLUME=Volume 11 - 2023 YEAR=2023 URL=https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2023.974850 DOI=10.3389/fpubh.2023.974850 ISSN=2296-2565 ABSTRACT=Background: - Currently, different COVID-19 vaccines are being developed and distributed worldwide to increase the proportion of the vaccinated people and as a result to halt the pandemic. However, the vaccination progress is different from place to place even among health care workers due to variation in vaccine acceptance. Therefore, this study aimed to assess the acceptance of COVID-19 vaccine and determinant factors among healthcare workers in west Gujji zone, southern Ethiopia. Method and materials: An institutional-based cross-sectional study design was employed to assess COVID-19 vaccine acceptance and associated factors among health care workers from July–August 2021. A simple random sampling technique was used to choose 421 representative healthcare workers from three hospitals in the west Guji Zone. The self-administrated questionnaire was used to collect data. Bivariate and multivariable logistic regression analyses were computed to identify factors associated with the acceptance of the COVID-19 vaccine. P-value < 0.05 was considered for significantly associated factors. Result:-From the representative health workers, 57%, 47.02%, and 57.9% of healthcare workers had good practice of COVID-19 prevention, adequate knowledge, and a positive attitude toward the COVID-19 vaccine consecutively. 38.1% of healthcare workers said they had a willingness to accept the COVI-19 vaccine. Profession (AOR-6, CI-2.92-8.22), previous history of vaccine side effects (AOR: 3.67, CI: 2.75- 11.41), positive attitude towards vaccine acceptance (AOR: 1.38, CI: 1.18-3.29), adequate knowledge towards COVID-19 vaccine (AOR: 3.33, CI: 1.36- 8.12), and adequate practice of COVID-19 prevention measure (AOR: 3.45, CI: 1.39- 8.61) were significant associated with COVID-19 vaccine acceptance. Conclusion: The proportion of COVID-19 vaccine acceptance among health workers was found to be low. From the study variables, profession, previous history of vaccine side effects, positive attitude towards vaccine acceptance, adequate knowledge to ward off COVID-19 vaccine, and adequate practice of COVID-19 prevention measures were significantly associated with COVID-19 vaccine acceptance.