AUTHOR=Wu Dongzhe , Qu Chaoyi , Huang Peng , Geng Xue , Zhang Jianhong , Shen Yulin , Rao Zhijian , Zhao Jiexiu 

TITLE=Better Life’s Essential 8 contributes to slowing the biological aging process: a cross-sectional study based on NHANES 2007–2010 data

JOURNAL=Frontiers in Public Health

VOLUME=Volume 12 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2024.1295477

DOI=10.3389/fpubh.2024.1295477

ISSN=2296-2565

ABSTRACT=Objective: This study examines the correlation between Life's Essential 8 (LE8) and Phenotypic Age Acceleration (PhenoAgeAccel) among U.S. adults to assess the impact of LE8 on biological aging, offering insights for public health strategies.

Methods: Data from 7339 participants aged 20+ in the 2007-2010 National Health and Nutrition Examination Survey (NHANES) were analyzed using weighted generalized linear regression and restricted cubic spline plots to explore linear and non-linear relationships between LE8 and PhenoAgeAccel, including gender-specific analyses.

Results: Analysis of NHANES participants divided into LE8 quartiles highlighted significant differences in demographic and health variables. Higher LE8 quartiles correlated negatively with PhenoAgeAccel in adjusted models (P<0.05), with significant trends observed in both genders (P<0.001 for males, P = 0.001 for females). No significant non-linear trends or interaction effects were found, except for BMI and diabetes status, which showed interaction effects (P<0.05).

Conclusion: Higher LE8 scores are significantly associated with reduced PhenoAgeAccel, underscoring the role of healthy lifestyle choices in mitigating biological aging. Despite its limitations, this study provides a foundation for health policy focused on lifestyle interventions, warranting further research on the causal relationships and cross-cultural applicability of these findings.