A prospective longitudinal approach to examine the association between social position in childhood, adolescence, and adulthood with the control of hypertension during adulthood

Introduction Hypertension is one of the main concerns in public health, since it is related with increased morbidity, and potential years of life lost in addition to loss of quality of life. This study aimed to assess: (1) the distribution of indicators of life course SEP in a cohort of Colombian patients with hypertension and (2) to assess the association of life course SEP and control of hypertension among this cohort of patients. Methods Data were obtained using the baseline survey of 258 patients from the Social Determinants and Inequities in the Control of Blood Hypertension Program (ProDSICHA). Mother occupation and housing conditions were measured with the Event History Calendar. Mother educational level was measured with the questionnaire developed by the Project on Ethnicity and Race in Latin America (PERLA). Socioeconomic position during adulthood was measured using education, occupation, and income level based in the MacArthur Network. Results The group with a higher lifelong social position and the group of lower lifelong social position showed better control of hypertension (OR = 1.21; p <0.05; OR = 1.33; p < .05, respectively) compared to those whose social position throughout life varied the most. No statistical differences were found in the relations between single lifetime social position variables, and hypertension control in the three time points analyzed. Discussion These findings warrant further research to deeper our understanding on the role of a multidimensional and cumulative approach of social position in hypertension control.


Introduction
Worldwide, hypertension has been considered one of the main public health problems (1).This condition is the most important modifiable risk factor for cardiovascular disease, the leading cause of death globally (1).In addition, hypertension negatively impacts patient's quality of life (2,3).Globally, evidence shows a stable age-standardized prevalence of hypertension among both men and women when comparing 1990 with 2019.This stability is a net effect of a decrease in high-income countries and an increase in some lowand middle-income countries (LMICs), including some in Latin America (4).Despite the consistent worldwide prevalence, the total count of individuals aged 30-79 years diagnosed with hypertension saw a two-fold increase.In 1990, there were 331 million women and 317 million men affected, and by 2019, this number had risen to 626 million women and 652 million men, primarily attributed to population growth and aging (4).Regarding treatment and control in LMIC during the same period, both improved in most countries since 1990, but the proportion of those treated who achieved control varied by more than four times across countries.However, akin to highincome countries, some in Latin America and the Caribbean demonstrated a closer alignment between treatment and control rates (4).
In Colombia, hypertension prevalence is between 24 and 31.1% (4,5).In addition, in the country, 76.3% of the women with hypertension are aware of their status, 63.9% are being treated, and 41% of hypertension in these patients is actually controlled (4).In men, data showed that 60.3% are aware of their health situation, 45.6% are being treated, and 24% have their hypertension controlled (4).Furthermore, reports about Colombia showed a high prevalence of risk factors associated with hypertension as follows: 56.5% of the population is overweight, 51.1% is sedentary (6), 23% smokes, and 61% has dyslipidemia (7), which place the population at a higher risk of coming to have hypertension.
Although hypertension has a significant impact on mortality and morbidity, there is a paucity of research on social determinants associated with hypertension control.Socioeconomic position (SEP) during the life course has been related to disadvantage processes that have implications for health outcomes across the lifespan (8,9).The life course approach posits that "combination, accumulation, and/or interaction of the social environments and biological insults experienced throughout the life course impact current and future events, environments, and health conditions and thus ultimately impact adult health" [(10), p. 2].To study the influence of SEP on cardiovascular research, the latent effects, pathways, social mobility, and cumulative life course models have been proposed.The operation of the hypothesis proposed by one or more of these models helps to explain the role of socioeconomic advantage or disadvantage in shaping cardiovascular risks and outcomes (10).

Effects of SEP on health
SEP has been related to health in general in such a way that the lower the occupied position in the social ladder, the worse the health outcomes in the individuals.Different studies have shown how socioeconomic disadvantage leads to poorer health outcomes [e.g., Shea et al. ( 9)], higher mortality [e.g., Brown et al. (11) and Stringhini et al. ( 12)], and a worse quality of life in general (13,14).Other studies have shown that subjective perception of socioeconomic status also has a relation with health status in adults [e.g., Demakakos et al. (15) and Richards et al. (16)].
There have been different efforts to conceptualize and explain how SEP and inequality in general can accumulate and affect individuals´ health and mortality.One such example is the cumulative inequality theory, which places macrostructural elements as the basis of health inequity (17).Furthermore, it specifies how these inequities are expressed "over the life course via demographic and developmental processes, and that personal trajectories are shaped by the accumulation of risk, available resources, perceived trajectories, and human agency" [(17), p. 334].Two important premises of this theory are that (1) inequality accumulates throughout life and (2) the life situation in childhood allows us to explain functioning levels and general wellbeing in adulthood (17).Also relevant is the idea that social systems are the ones that generate inequality (17,18).
Another important piece of the puzzle that allows us to deepen this topic is the accumulation of risk models, which also suggest that "childhood circumstances set individuals on diverse social, economic, and behavioral trajectories that in turn affect health" [(19), p.139].In this sense, early social disadvantages begin a chain of negative influences that are later reflected in worse health and premature death (19,20).From a structuralist approach, there are several influences that have been considered to affect health and which are deeply linked with SEP.Some examples are diet, housing, working conditions, exposure to air pollution, and access to health services (21).Another approach is related to the psychological stress that could be present in deprived situations.It has been pointed out that the perceived stress that individuals might experience in adverse psychological or material situations can have a negative impact on health (22).

SEP in childhood and health outcomes in adulthood
Adult health status has been related to social circumstances across the life course, particularly with socioeconomic conditions (e.g., [23][24][25].For example, adverse childhood experiences have been related to long-term physical health consequences [e.g., Monnat and Chandler (26) and Nurius et al. ( 27)].Furthermore, results from a systematic review showed that childhood and adolescent socioeconomic circumstances were determinants for adulthood's greater risk for cardiovascular disease (28).Moreover, some studies have shown that this effect is independent of SEP in adulthood (29).
In this regard, evidence also shows a relationship between SEP during childhood and high adult blood pressure (23,30) which accounts for the importance of early life in the development of hypertension (31).Nevertheless, there is also contrary evidence that reports no relationship between those variables along the individuals´ life course (29).It is worth mentioning that the studies that found no relationship used mostly correlational and prospective designs (trend studies), while studies that found an association between childhood SEP and adult blood pressure were prospective cohort studies (29).
A way of approaching methodologically and theoretically to life course and particularly childhood and adolescence SEP indicators is through some parents´ variables [e.g., Galobardes et al. (32)].For instance, studies showed that housing conditions during childhood and adolescence are associated with poor health outcomes such as respiratory infections, asthma, lead poisoning, injuries, and mental health (33).In addition, parent's education influences health in older ages.A study found that the mother's education level (but not the father's) was associated with self-rated adult health at ages 33 and 42 years: the higher the educational level achieved by the mother, the better health status perceived (34).Moreover, a study in rural Uganda showed that the mother's education level (but not the father's) was an independent predictor for better health and nutrition among infants and young children (35).Another study found that the higher the level of a mother's education, the higher the direct effect on child health.In this study, no statistical differences were found regarding the father's education level (36).Another important reference for our study is the Jackson Heart Study (37), whose results showed that a higher mother's education was protective of hypertension prevalence in adulthood.Thus, these studies suggest that a mother's education plays a key role in predicting health outcomes in her offspring.
Regarding parents' occupation, the study by Pinilla et al. (38) showed that parental occupation is associated with the probability of reporting good health in adults ages.The study also reported that the father's occupation effect was more important than the mother's.In this same study, results showed that children of those women in top occupations show the highest probability of having good health.
In Latin America, there is a paucity of research about the role of SEP and cardiovascular risk factors during the life course.This is problematic, as SEP throughout one's life may contribute to understanding the cardiovascular profile within and between Latin American countries.In addition, to the best of our knowledge, there is no research in Colombia studying the role of life course SEP on hypertension control in adulthood.Since hypertension remains a public health problem in low-and middle-income countries (39), including those in Latin America, it is important to deepen our understanding of the influence of life course SEP variables on this condition, particularly in the context of Colombia, one of the most economically unequal countries in the world.To contribute to the literature on this subject, the present study aims to test the model shown in Figure 1.
Considering the above conceptualization, the aims and hypothesis of this study are as follows: Aim 1: The first objective of this study is to assess the distribution of indicators of life course SEP in a cohort of Colombian patients with hypertension.
Aim 2: The second objective of this study is to assess the association of life course SEP and control of hypertension among this cohort of patients.

Method Data
Data for this study came from the Social Determinants and Inequities in the Control of Hypertension Program (ProDSICHA for its Spanish acronym) project.This was a prospective longitudinal study that included hypertension patients from 45 to 70 years who participated in hypertension programs in Colombia.ProDSICHA study aimed at furthering our understanding of the effects of social determinants of hypertension control in three Colombian cities.There were three data collection periods for this project.The assessments took place between 2015 and 2018.This study was approved by the Universidad de los Andes Ethics Committee (Act number 531 of 2015).

Population and sample
We designed the sample using a multi-stage sampling strategy (cities, institutions, and participants).In phase one, we selected three cities using heterogeneous criteria to examine the variations and similarities that the phenomenon may present in different contexts (40).We selected Bogotá, Medellín, and Quibdó, considering differences in poverty levels, health service infrastructure, and city size.In phase two, we selected healthpromoting entities (HPEs) that had established a hypertension control program through their network of healthcare providers.In some HPEs, the majority of affiliates belonged to the subsidized regime, which covers people without the ability to pay and the most vulnerable population in the country classified according to the Beneficiary Selection System, while in others, the majority belonged to the contributory regime, which requires a monthly contribution from affiliated persons and covers employees under labor contracts in the public or private sector, pensioners, and independent workers with the ability to pay, as well as the beneficiaries of the affiliate.
Other selection criteria for the HPEs included coverage equal to or greater than the pre-determined sample size of each city, the existence in these institutions of an updated record of their service users, and the institution's agreement to participate in the study.In phase three, we selected the participants from a list obtained from each HEP.A stratified probability sampling strategy was used based on age and gender distribution.
The inclusion criteria for the participants were as follows: adults aged between 45 and 70 years with diagnosed hypertension, participants of ProDSICHA at the selected institution, and managed as outpatients.Participants with cognitive, neurological, psychiatric, or motor impairments that hinder response capacity to psychological tests were excluded.We used data from the three waves of the ProDSICHA project.
Participants were contacted to respond to the questionnaire in the three waves of the study.If, after three unanswered calls, it was not possible to contact the participant, the reference contact provided by the person was called (if this contact was not successful after three call attempts, the participant was withdrawn from the study).In each city and wave, the interviews and measurements were conducted at the affiliated university campus.All participants were reimbursed for transportation from their residence to each campus.

Instruments and measurements SEP during childhood and adolescence Mother's occupation
In the Event History Calendar developed, we included the questions "What was your mother's occupation when you were 7 years old?" and "What was your mother's occupation when you were 14 years old?. " Response categoric options were "employee, " "freelance, " "unemployed, " "student, " "employee and student, " "unpaid homework, " "housewife or husband, " "retired, " "absent, " "passed away, " "do not know, " "do not answer, " and "does not apply."

Mother's educational level
We used the questionnaire developed by the Project on Ethnicity and Race in Latin America (PERLA) (41), specifically, the question "What is or was the highest educational level completed by your mother?. " The response options were categoric and varied between "none" and "postgraduate."

Housing conditions
To assess objective housing conditions during childhood and adolescence, an Event History Calendar was developed for this study.Specifically, we used the questions: "What material was your home mainly when you were 7 years old?" and "What material was your home mainly when you were 14 years old?. " The response options were six categoric items: "cement mainly, " "wood mainly, " "other, " "do not know, " "do not answer, " and "does not apply."

SEP during adulthood
To assess socioeconomic position during adulthood, we used three variables based on the McArthur Network: education, occupation, and income level.To measure education, we asked participants what level of education they had reached.Response options were elementary school, high school, elementary school incomplete or no studies, technical or technological studies, university degree, and a postgraduate degree.For the purpose of statistical analysis, we categorize the variable into three options: "less that elementary school, " "high school, " and "more that high school." To measure occupation, we asked participants which options best described their work.Response options were student, retired, housekeeper, employee and student, independent worker, employed, and unemployed.In the analysis, the variable was categorized into "employed, " "unemployed, " "housekeeper, " and "retired." Finally, we measured the income level by asking participants "¿How much did you earn last month?. " Response options vary between "Less than a current legal minimum wage" and "More than 16 current legal minimum wages, " with eight more response options in between.In the analysis, we categorized the variable into "less than 168 US dollars" and "more than 168 US dollars."

Life course SEP
We developed a combined indicator for SEP across childhood, adolescence, and adulthood.This indicator addressed the multidimensionality of SEP by accounting for different dimensions of SEP, such as occupation, income of participant, education, and housing conditions across different epochs.The construction of this indicator was carried out in two phases.In phase 1, we assigned scores for each of these socioeconomic indicators, and in phase 2, we summed these scores.The final score ranged from 0 (worse) to 13 (good).Occupation scores ranged from 1 to 4, with 4 being those with mother employed in childhood and adolescence and participant employed in adulthood, 2 and 3 being different combinations of mother's employment status during childhood and adolescence and participant occupation, and finally, 1 was assigned to those whose mother was unemployed in childhood and adolescence and the participant was unemployed.The income of the participant was used as a two-level indicator, with 1 being income ≤168 US dollars (below legal minimum wage) and 2 > 168 US dollars (above legal minimum wage), based on the survey response categorization.Education scores were created based on the mother's education in childhood and adolescence, and they ranged from 1 to 3, with higher scores reflecting a higher level of education (high school or more).Finally, housing scores ranged from 1 to 2, with 2 being those who lived all their lives in cement-constructed homes (in Colombia, houses built with cement, compared to other materials, tend to be more expensive and durable).Continuous life course SEP indicator was categorized as low (<5), medium (5-7), and high (>8) based on its quartile distribution.

Hypertension control measure
To measure blood pressure, we used a digital blood pressure monitor whose brand is OMRON ® BP710.We defined control of hypertension among those with hypertension as having diastolic and systolic blood pressure below 140 and 90 mmHg, respectively (42).At each year of assessment, hypertension control was determined.

Statistical methods
Exploratory data analysis techniques such as histograms, QQ-Plots, box-plots, scatterplots, and basic descriptive (means, medians, and IQR) were used to assess the distribution of dependent and independent measures.Frequency distributions of the outcome will be used to identify the distribution of outcomes, which in turn will be conducive to determining the appropriate modeling strategies.In addition, these techniques will also be used to explore the most informative transformations of the covariates, confounders, and relevant predictors considered in the analysis.Extreme values were examined using the Tukey-Fences approach, and their removal from the analysis was determined.Missing patterns and rates were assessed.Since rates were < 5%, a complete case analysis was considered.
For Aim 1, we considered descriptive statistics for the life course SEP overall and by city.Comparisons were addressed using standardized differences, SD; if SD > 0.2, we claimed statistical differences across cities of a cumulative social indicator.
For our specific Aim 2 and related hypothesis, we used a generalized linear mixed model (GLMM) with random intercept, with normal distribution, identity link, and exchangeable correlation matrix.GLMM models account for the repeated nature of the outcome as well as the clustering of patients within institutions and institutions within cities.Given the low number of selected cities (3) and institutions, we will not focus on estimating these effects, but rather GLMM will allow us to use the Huber-White standard error estimates, also known as "robust standard error" or "sandwich variance" estimates.In the case of a linear model with a working independence variance structure, these are known as "heteroscedasticity consistent standard error" estimators.They are a popular alternative to the likelihood-based generalized linear mixed model, which is more sensitive to variance structure specification.Potential multicollinearity between relevant predictors was assessed using variance inflation (VIF) analysis.No predictors had VIF > 10.
Using the second hypothesis of Aim 2 as an example, the proposed model can be written as

e Covariates
Where p = P (Hypertension Control = 1), the life course SEP score is a categorical measure, taking 1 for low SEP and 3 for high SEP.Time is a categorical variable, taking the values of 1, 2, and 3 for each time when hypertension was measured.Appropriately indicating the categorical nature of the predictors, we will obtain one less than levels parameter estimates.Thus, for life course SEP (using reference = 2), we expect to estimate 2 parameters (β β 11 13 , , ) and , 2 for time, and 2 for the LCSP*time interaction.All models were adjusted for demographic variables such as age, gender, race/ethnicity, and years in the hypertension program.

Results
There were 258 participants recruited at baseline.In Table 1, we present some demographic information regarding the sample stratified by epoch.
Table 2 shows a comparison of sociodemographic characteristics of participants across the three waves.The main differences in the composition of the sample were when comparing time 1 and 2, as well as time 1 and 3, while it was more stable between time 2 and 3.
Table 3 shows the changes in the blood pressure of the participants of the study at the three time points assessed.These results show that patients had progressively lower systolic blood pressure and higher levels of hypertension control.
Table 4 shows models to address the first objective of the study, i.e., to assess the distribution of individual variables of life course SEP.Results show that none of the variables included in the model predict the control of hypertension in the sample.
Table 5 shows the estimates for hypertension control, with the different variables measured in the participant (excluding mother variables).
Results show that there is no effect of the variables in the model in the control of hypertension.
Table 6 shows models to address the second hypothesis of the last objective of the study, which sought to assess the association of the combined life course SEP and control of hypertension.
In these models, we found significant associations between the combined effect of life course SEP and the control of hypertension in both groups.In this sense, the group with a higher lifelong SEP and the group with a lower lifelong SEP showed better control of hypertension (OR = 1.21; p < 0.05; OR = 1.33; p < 0.05, respectively) compared to those whose SEP throughout life varied the most.

Discussion
In this study, we aimed to have a deeper understanding of the role of life course SEP variables and hypertension control in a Colombian sample of individuals who were part of programs for the control of this chronic condition.
Descriptive results revealed that there were more women than men in this sample, with 58.1% of the participants having completed at least a high school level, which we can consider an educated sample considering the Colombian context [data from 2014 showed that only 44% of the population with ages between 24-and 65-years old population had an upper secondary education; (43)].
Regarding hypertension control, most of the sample was controlled, especially at Time 3. Our results show that patients had progressively lower systolic blood pressure and higher levels of hypertension control throughout time.This suggests that this sample had a high level of control when compared to other studies in Colombia, which reported much lower levels (7,44,45).These differences might be explained by the higher levels of adherence to the treatment found in another study with this same sample, particularly in terms of pharmacological treatment adherence (46).In addition, An important issue is that the programs for hypertension control used to have an emphasis on medications, neglecting health promotion and disease prevention interventions.These interventions are part of an integral approach to health.In such an approach, structural aspects of individuals' lives need to be considered.The comprehension of the multidimensional processes that determine individual and collective health conditions ( 48) is essential to address the fundamental causes of the disease and improve the type of interventions available to the population.
Regarding the second objective of the study, we aimed to understand the role of different SEP variables throughout the lifetime (childhood, adolescence, and adulthood) in the hypertension control odds for three time points (T1, T2, and T3).
In the model using different SEP variables throughout the lifetime (see Table 5), results showed no association between single life course SEP indicators and hypertension control in the three time points analyzed.In this sense, our results are different from those reported in the literature.For example, in the Jackson Heart Study that assessed life course socioeconomic status and hypertension (37), results found that mothers´ education of at least a high school degree was associated with lower incident and prevalent hypertension ratio in adults.In our study, we did not find a relationship between the mother's educational levels and the control of hypertension.In the same direction, the mother's occupation was pointed out as a good predictor of health status in adulthood (38).In these tested models (SEP variables included as independent factors to predict hypertension control in adulthood), we did not find the same tendency in the data.It is important to note that in this study, we did not include paternal education and occupation because, in the literature reviewed, we found a prevalence of maternal variables to explain the health status of their child in adulthood.In addition, in the Colombian context, 69.7% of the households are female-headed, without the presence of a spouse, which means that women are very much in charge of educating and raising their children (49).
In a similar way, poor housing conditions have been pointed out as having a negative impact on health status (33, 50), but we could not prove this effect in this first model tested.
In our results, we did not find a relationship between adulthood SEP indicators and the control of hypertension.Although evidence shows that a high adult income and a higher occupation are inversely associated with hypertension management (51), our results were different from those reported in the literature.Nonetheless, it is important to stress that although our models that aimed to test the effect of SEP variables on hypertension control independently did not show statistically significant associations, when we tested the effect of the lifelong SEP (as a whole effect), we were able to find significant results.Those results are discussed below.
To inquire about the cumulative effects of SEP in hypertension control, we created a combined indicator of lifelong SEP (see Figure 1).Results showed that there is a differential effect of SEP over time in the control of hypertension.Those who kept a higher SEP during childhood, adolescence, and adulthood showed better control of hypertension in comparison with those whose SEP throughout life varied the most.Similarly, those with a lower lifelong SEP showed better control of hypertension in comparison to those whose SEP was changing throughout life.The previous results seem to support that having a changing SEP throughout life negatively affects the probability of hypertension control (see Table 6).This might be related to a less stable SEP, either because it increases or because it decreases over time.In sum, these results did not show evidence of SEP accumulative effects but did show evidence of downward and upward mobility effects.
While research on the impact of changes in SEP throughout the lifespan on health is relatively understudied (52), particularly in hypertension (53), it is well-established that individuals who maintain a relatively high SEP throughout their life course are more likely to experience better health, whereas those who consistently have a relatively low SEP or downward social mobility tend to experience negative health outcomes (52)(53)(54).In this regard, the aforementioned finding may seem somewhat counterintuitive.
However, there are two potential explanations for it.First, studies have shown that social changes at the societal level are associated with higher personal stress because they disrupt lifepaths and might be linked to more potentially stressful circumstances (55).Changes in SEP might have a similar effect, leading to new stressful situations for individuals and resulting in a diminished sense of control, feelings of alienation, and experiences of discrimination throughout their lives.In fact, while downward social mobility can lead to stress and mental and physical disadvantages, upward mobile individuals can benefit from material wealth, prestige, power, and wellbeing.However, this may come at the expense of experiencing stressors hypothesized to lead to unhealthy behaviors and dysregulation of biological systems (56).If changes in both socioeconomic directions occur frequently, they might activate neuroendocrine mechanisms with implications for cardiometabolic health (53,56), including increasing blood pressure (53,57).In sum, changes in SEP throughout one's life may challenge the individual's homeostatic balance.Second, in the Colombian context, a potential mechanism to explain this finding is that individuals who maintain a stable SEP throughout their lives may not have experienced changes in their health insurance regimen (contributory or subsidized).Since both regimens cover the treatment of hypertension, having a stable SEP could contribute to maintaining the affiliation to the same regimen, ensuring regular access to medication for controlling this chronic condition.In contrast, those who undergo changes in SEP during their life course are more likely to experience changes in their insurance affiliation, as they have to switch between regimens when their SEP changes (e.g., due to changes in occupational status or income).In this regard, a study in Colombia revealed high drop-out rates in a cohort of individuals affiliated with HEP, one of the explanations being a change in the occupational status of the participants (58).Thus, administrative barriers associated with the continuity of care and medications can lead to decreased control in individuals experiencing changes in their SEP and type of health insurance status.
This suggests that while the literature on social mobility and cardiovascular health supports the benefits of upward SEP through social policies aimed at reducing disadvantages across the lifespan (52,53), having universal coverage in health insurance, as is almost the case in Colombia, might protect the most vulnerable population from a lack of access to healthcare.This, in turn, allows them to have similar results in controlling hypertension as those with a stable high SEP.Future studies have to rule out other mechanisms to explain this finding.
We would like to point out some of the limitations of this study.In this sample, we included an urban sample, leaving out an important part of the Colombian population that lives in rural settings; the previous would limit the adoption of a territorial approach in future decision-making, which is particularly important in a country such as Colombia, with a huge extension of rural and peasant territories.In addition, evidence shows a lower prevalence of hypertension in urban areas in Colombia (21%) in comparison with rural areas (34%) or mixed urban-rural areas (35%) (5), which points to a need to have a deeper understanding of rural territories in the future.Another limitation is that we did not include the father's education and occupation during childhood in the analysis, and future studies should take this variable into account.In different cultures where the father is more present in raising children and contributing financially to the home, this variable becomes relevant.In addition, it is important to note that the study had a relatively small sample size, which could have an impact on the conclusions drawn.However, as we used a longitudinal design, this may potentially provide more power to the analysis performed.

Conclusion
In this study, we aimed to address lifelong SEP variables and their relationship with hypertension control in Colombian adulthood, assessed at three different time points.This study contributes to the current body of research in the sense that there are relatively few studies exploring the relationship between social mobility variables and the control of hypertension.Most studies in the field of social mobility and health focus on looking at the relationship between SEP variables across the lifespan and their relationship with the prevalence and or incidence of cardiovascular disease, including hypertension  (53)].In this study, we found that a stable SEP has a positive effect on hypertension control.
We contribute to this research by providing evidence that stable high or low SEP can experience benefits in hypertension control compared to those who undergo social mobility throughout their lives.While this may seem counterintuitive, it could be attributed to the stress associated with social mobility and the protective effects of health insurance among those with low, stable SEP in Colombia.

Hypothesis 1 :Hypothesis 2 :
Single-life course SEP indicators (childhood, adolescence, and adulthood) are directly associated with hypertension control.Combined life course SEP indicators are directly associated with hypertension control.

TABLE 1
Demographics of hypertensive patients assessed by epoch.
*Time 2 and Time 3 are not presented on the table since sociodemographic indicators were measured only in Time 1.

TABLE 2
Comparison of baseline characteristics of participants' contribution to different times.

TABLE 3
Mean and standard deviations for blood pressure and control of hypertension in the three time points assessed.

TABLE 4
Aim 1 models: multivariate models estimates for control.
Models adjust for age, gender, race/ethnicity codes as white/mixed race (ref), black/mulatto, and other years in the HTA program.

TABLE 5
Aim 2 model: mixed model estimates for control with different indicators used.

TABLE 6
Aim 2 model: mixed models estimates for control.
Models adjust for age, gender, race/ethnicity codes as white/mixed race (ref), black/mulatto, and other years in the HTA program.