AUTHOR=Barouki Robert 

TITLE=A toxicological perspective on climate change and the exposome

JOURNAL=Frontiers in Public Health

VOLUME=Volume 12 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2024.1361274

DOI=10.3389/fpubh.2024.1361274

ISSN=2296-2565

ABSTRACT=Climate changes is accompanied by changes in the exposome, including increased heat, ground-level ozone and other air pollutants, infecQous agents, pollens, and psycho-social stress. These exposures alter the internal component of the exposome and account for some of the health effects of climate change. The adverse outcome pathways describe biological events leading to an unfavorable health outcome. In this perspecQve I propose to use this toxicological framework to beTer describe the biological steps linking a stressor associated with climate change to an adverse outcome. Such a framework also allows to beTer idenQfy possible interacQons between stressors related to climate change with others such as chemical polluQon. More generally, I call for the incorporaQon of climate change as part of the exposome and for an improved idenQficaQon of the biological pathways involved in its health effects.