AUTHOR=Martín Moreno Vicente , Martínez Sanz María Inmaculada , Fernández Gallardo Miriam , Martín Fernández Amanda , Benítez Calderón María Palma , Alonso Samperiz Helena , Pérez Rico Elena , Calderón Jiménez Laura , Guerra Maroto Sara , Sánchez Rodríguez Elena , Sevillano Fuentes Eva , Sánchez González Irene , Recuero Vázquez Miguel , Herranz Hernando Julia , León Saiz Irene TITLE=The influence of nationwide COVID-19 lockdown on the functional impairment and long-term survival of dependent people for carrying out basic activities of daily living in a neighborhood of the city of Madrid, Spain: Orcasitas Cohort Longitudinal Study JOURNAL=Frontiers in Public Health VOLUME=Volume 12 - 2024 YEAR=2024 URL=https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2024.1385058 DOI=10.3389/fpubh.2024.1385058 ISSN=2296-2565 ABSTRACT=Background: Prolonged confinement can lead to personal deterioration at various levels. We studied this phenomenon during the nationwide COVID-19 lockdown in a functionally dependent population of the Orcasitas neighborhood of Madrid, Spain, by measuring their ability to perform basic activities of daily living and their mortality rate.Methods: A total of 127 patients were included in the Orcasitas cohort. Of this cohort, 78.7% of the patients were female, 21.3% were male, and their mean age was 86 years. All participants had a Barthel index ≤60. Changes from pre-to postconfinement and 3 years afterward were analyzed, and the effect of these changes on survival was assessed (2020)(2021)(2022)(2023).The postconfinement functional assessment showed significant improvement in independence over preconfinement for both the Barthel score (t = -5.823; p <0.001) and the classification level (z = -2.988; p <0.003). This improvement progressively disappeared in the following 3 years, and 40.9% of the patients in this cohort died during this period. These outcomes were associated with the Barthel index (z = -3.646; p <0.001) and the level of dependence (hazard ratio 2,227; CI 1,514-3.276). Higher mortality was observed among men (HR 1,745; CI 1,045-2,915) and people with severe dependence (HR 2.169;. Setting the cutoff point of the Barthel index at 40 provided the best detection of the risk of death associated with dependence.Conclusions: Home confinement and the risk of death due to the COVID-19 pandemic awakened a form of resilience in the face of adversity in the population of functionally dependent adults. The Barthel index is a good predictor of mortality in the medium and long term and is a useful method for detecting populations at risk in health planning. A cutoff score of 40 is useful for this purpose. The noninstitutionalized dependent population is, to a certain extent, an invisible population. Future studies should analyze the causes of the high mortality observed.