AUTHOR=Roca-Ventura Alba , Solana-Sánchez Javier , Cattaneo Gabriele , Tormos-Muñoz Josep M. , Pascual-Leone Álvaro , Bartrés-Faz David TITLE=Lifestyle trajectories in middle-aged adults and their relationship with health indicators JOURNAL=Frontiers in Public Health VOLUME=Volume 12 - 2024 YEAR=2024 URL=https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2024.1412547 DOI=10.3389/fpubh.2024.1412547 ISSN=2296-2565 ABSTRACT=Understanding the impact of diverse lifestyles on health preservation and disease risk is crucial for effective interventions. In this study, lifestyle engagement over five years was analyzed in 3,013 healthy adults aged 40-70 from the Barcelona Brain Health Initiative using K-means clustering. Nine modifiable risk factors were considered, including cognitive, physical, and social activity, vital plan, diet, obesity, smoking, alcohol consumption, and sleep. The data-driven analysis classified subjects into five lifestyle profiles, revealing associations with health behaviors and risk factors. Those exhibiting high scores in health-promoting behaviors and low-risk behaviors, demonstrate a reduced likelihood of developing diseases (p<0.001). In contrast, profiles with risky habits showed distinct risks for psychiatric, neurological, and cardiovascular diseases. Participant's trajectories in lifestyles remained relatively stable over time. Data-driven insights emphasize the importance of maintaining a healthy lifestyle, informing personalized interventions to enhance health outcomes in an aging society.