AUTHOR=Chen Jing , Xiang Qian , Wu Jia-yu , Zheng Xiao-Jia , Jiang Xiao-yan 

TITLE=Characteristics and risk factors for infection and mortality caused by Klebsiella pneumoniae in patients with acute pancreatitis

JOURNAL=Frontiers in Public Health

VOLUME=Volume 12 - 2024

YEAR=2025

URL=https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2024.1533765

DOI=10.3389/fpubh.2024.1533765

ISSN=2296-2565

ABSTRACT=BackgroundThe purpose of this study is to investigate the risk factors for carbapenem-resistant Klebsiella pneumoniae (CRKP) infection and death of K. pneumoniae infections in acute pancreatitis (AP) patients.MethodsThis was a retrospective analysis of AP patients with K. pneumoniae infection between January 2019 and April 2024. Logistic regression model was used to determine the risk factors for acquisition of CRKP. Cox proportional hazards regression model was used to identify risk factors for mortality of K. pneumoniae infection.ResultsA total of 113 AP patients experienced K. pneumoniae infections, including 66 with CRKP infection and 47 with CSKP infection. The mortality rate of these patients was 36.3%, with a significantly higher mortality rate in the CRKP group than in the CSKP group (P < 0.001). Only mechanical ventilation (OR = 2.301; 95% CI 1.02-5.20; P = 0.045) was the independent risk factor for CRKP infection in patients with AP. Surgery (HR 0.38; 95% CI 0.20–0.75; P = 0.005) and mechanical ventilation (HR 2.93; 95% CI 1.10–7.82; P = 0.032) were the independent risk factors associated with mortality of K. pneumoniae infection in patients with AP.ConclusionKlebsiella pneumoniae infection has become a threat to patients with AP. Therefore, implementing preventive and control measures based on risk factors is crucial for the prognosis.