AUTHOR=Zhuang Qian , Wang Huan , Bai Qiqi , Liang Jingwen TITLE=The impact of the relationship between government and pharmaceutical enterprises on social contribution during the public health emergency: an empirical study JOURNAL=Frontiers in Public Health VOLUME=Volume 13 - 2025 YEAR=2025 URL=https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2025.1494922 DOI=10.3389/fpubh.2025.1494922 ISSN=2296-2565 ABSTRACT=IntroductionDuring the COVID-19 pandemic, vaccines and specific drugs are seen as indispensable solutions to ending or responding to the pandemic, and pharmaceutical enterprises are in the spotlight. The Chinese government has made active efforts to guide pharmaceutical enterprises to make appropriate social contribution during the public health emergency. This study explores how government-enterprise relationship promotes this process.MethodsUsing the financial and textual data of China's listed pharmaceutical companies and policy data from the official website of the Chinese health-related government departments, this study drew the social contribution through text analysis, and established the response index of pharmaceutical companies to the government—the government-enterprise alignment index (GE_Ali) based on the formula of elasticity for reference. Then a series of regressions are used to do the empirical tests.ResultsThis study found the more responsive pharmaceutical companies were to government, the greater their contribution to society during the pandemic, mainly through increasing the intensity of drug R&D, production and promotion, and the good communication mechanism between the two formed a mediating effect.DiscussionThe nature of state ownership, the presence of embedded party organizations, and the location in the provincial capital city had significant effects on the realization of a high level of government-enterprise alignment positively affecting the social contribution. This study confirms that the Chinese government has made enterprises a part of social governance, which is a global hotspot, through the embedding of party organizations. It also indicates that the government needs to re-recognize its key role in shaping social contribution, especially in distinguishing its responsibilities between normal and emergency situations.