AUTHOR=Wang Jiang , Duan Lanzhi , Zeng Rui , Xie Fayi , Wu Zhigang , Luo Yanhong , Zhang Xiaoming , Li Wei , Ye Dongmei , Zhu Ke , Fan Tenghui , Zhu Aizhang , Chen Lihuan , Zhu Wan , Zhao Yueyue , Hu Hongmei , Xiao Yi 

TITLE=Change in depressive symptom scores to assess the risk of new-onset dual sensory impairment in middle-aged and older adults: a nationwide cohort study

JOURNAL=Frontiers in Public Health

VOLUME=Volume 13 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2025.1520552

DOI=10.3389/fpubh.2025.1520552

ISSN=2296-2565

ABSTRACT=BackgroundEvidence of the association between change in depressive symptom scores and new-onset dual sensory impairment (DSI) remain underexplored. We aimed to investigate the relationship between depressive symptom scores and the risk of new-onset DSI in middle-aged and older adults.MethodsThe study included 3,237 participants. The Center for Epidemiologic Studies Depression Scale (CES-D-10) was used to assess depression symptoms. CES-D-10 scores were classified according to the K-means cluster analysis. Subsequently, the logistic regression analysis was used to determine the association between the change in CES-D-10 scores and DSI. Additionally, restricted cubic splines (RCS) were employed to examine whether there was a linear correlation between cumulative CES-D-10 scores and DSI. We also explored whether the association of CES-D-10 scores with DSI varies across different subgroups.ResultsOne thousand and sixty one out of 3,237 participants had a new-onset DSI during 3 years. Compared to class 1 with the best control of depressive state, the OR for class 2 with good control was 1.54 (95% CI, 1.28, 1.85), the OR for class 3 with moderate control was 1.59 (95% CI, 1.22, 2.07), the OR for class 4 with worse control was 1.62 (95% CI, 1.31, 2.02), and the OR for class 5 with consistently high levels was 1.86 (95% CI, 1.34, 2.57).ConclusionsIndividuals exhibiting suboptimal management of depressive symptoms were more susceptible to developing new-onset DSI, underscoring the need for early depression screening and assessment in the preventative strategies for new-onset DSI.