AUTHOR=Pozet Astrid , Falcoz Antoine , Roller Cécile , Jai Taha , Meurisse Aurelia , Nerich Virginie 

TITLE=Health-state utility values and their time to deterioration in informal caregivers of older patients with chronic diseases

JOURNAL=Frontiers in Public Health

VOLUME=Volume 13 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2025.1531608

DOI=10.3389/fpubh.2025.1531608

ISSN=2296-2565

ABSTRACT=ObjectivesThis study aimed to assess health state utility values (HSUVs) in caregivers of older patients with chronic diseases receiving or not receiving social worker support.MethodsThis multicentric open-label randomized study assigned caregivers to receive either an informational booklet alone or one accompanied by social worker support. Caregivers completed EQ-5D-3L each semester for 24 months. We reported caregiver HSUVs at baseline and after 6, 12, 18, and 24 months using EQ-5D-3L utility index scores and exploring their time to deterioration (TTD).ResultsAmong 179 included caregivers, the percentage reporting some or extreme problems on five EQ-5D-3L dimensions remained almost stable over time with a median EQ-5D-3L utility index score of 0.89 [0.80–1.00] at baseline (n = 177), 0.80 [0.80–0.89] at M6 (n = 125), and 0.80 [0.73–0.91] at M24 (n = 81). Among the respondents, 62% (n = 109) experienced a deterioration in EQ-5D-3L utility index score, with a median TTD of 9.1 months [95%CI 6.2–14.9] in the control group (CG) and 9.5 months [6.3–14.4] in the supportive intervention group (SIG) (HR = 1.06 [0.73–1.54]), p-value = 0.76.ConclusionOur study provides a catalog of HSUVs across different caregiver profiles and at various follow-up time points, which can inform future economic evaluations.Clinical trial registrationClinicalTrials.gov, NCT02626377.