AUTHOR=Han Joohun , Durand-Morat Alvaro , Mottaleb Khondoker TITLE=Vitamin A fortification: key factors and considerations for effective implementation JOURNAL=Frontiers in Public Health VOLUME=Volume 13 - 2025 YEAR=2025 URL=https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2025.1534375 DOI=10.3389/fpubh.2025.1534375 ISSN=2296-2565 ABSTRACT=Vitamin A fortification plays a crucial role in achieving long-term economic development in developing countries by supporting the growth and development of human capital. While fortification programs involve a range of nutritional, agricultural, economic, and political considerations, there is a lack of a comprehensive overview of the topic in the literature. Our review highlights the importance of holistic approach in designing fortification programs: the effective program should consider (a) the agronomic, economic, and administrative capability of the target regions in regard of fortification method and vehicle to maximize effectiveness; (b) strategies to ensure the producers' and consumers' adoption to enhance uptake rate; and (c) evaluate outcomes with respect to economic metrics rather than focusing solely on before-and-after comparison to avoid biased assessment.