AUTHOR=Wu Jiajun , Cui Shaoqian , Li Xuekui , Zhang Xiaofei , Yang Siqi , Sun Junhao , Jiang Xiubo 

TITLE=Association between polycyclic aromatic hydrocarbons exposure and metabolic dysfunction-associated steatotic liver disease in US adults

JOURNAL=Frontiers in Public Health

VOLUME=Volume 13 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2025.1540357

DOI=10.3389/fpubh.2025.1540357

ISSN=2296-2565

ABSTRACT=ObjectiveTo investigate the individual or combined effects of polycyclic aromatic hydrocarbons (PAHs) on metabolic dysfunction-associated steatotic liver disease (MASLD) in U.S. adults.MethodsWe enrolled 3,130 participants aged 20 and over from the 2007–2016 National Health and Nutrition Examination Survey (NHANES) and analyzed six urinary PAH metabolites. The Poisson regression, Bayesian kernel machine regression (BKMR), and weighted quantile sum (WQS) regression models were used to assess the associations between PAHs and MASLD.ResultsAfter adjusting for covariates, Poisson regression model showed significant associations [RRs (95% CIs)] between higher exposure quartiles of 2-hydroxynaphthalene (2-NAP) [Q2: 1.35 (1.06, 1.73); Q3: 1.67 (1.35, 2.07); Q4: 1.62 (1.23, 2.15); p-trend < 0.001], 2-hydroxyfluorene (2-FLU) [Q3: 1.36 (1.08, 1.70); p-trend = 0.073], 1-hydroxyphenanthrene (1-PHE) [Q4: 1.35 (1.03, 1.76); p-trend = 0.009], and 1-hydroxypyrene (1-PYR) [Q3: 1.37 (1.12, 1.69); Q4: 1.33 (1.01, 1.76); p-trend = 0.025] and MASLD (p < 0.05), compared with Q1. BKMR model exhibited a positive trend between mixed PAHs and MASLD. The WQS index constructed for six PAHs was significantly related to MASLD [OR (95% CI): 1.25 (1.06, 1.49)].ConclusionThis study suggests that exposure to PAHs, individually or in combination, may be associated with an increased risk of MASLD.