AUTHOR=Shete Priya B. , Santos Nicole , Spindler Hilary , León Tomás , Petersen Maya , Kilpatrick A. Marm , Jain Seema , Watt James , Radhakrishna Rohan , Pan Erica , Aragón Tomás TITLE=Building an agile state-wide research infrastructure to address COVID-19 and emerging threats: insights from an equity-centered public health and academic collaboration in California JOURNAL=Frontiers in Public Health VOLUME=Volume 13 - 2025 YEAR=2025 URL=https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2025.1549326 DOI=10.3389/fpubh.2025.1549326 ISSN=2296-2565 ABSTRACT=The COVID-19 pandemic underscored the need for efficient real-time evidence generation to inform public health interventions and policies. To address this gap, a formalized research partnership between the California Department of Public Health (CDPH) and the University of California (UC) was created. The aim of this case study is to describe the achievements and lessons learned from the California Collaborative for Public Health Research (CPR3). This state-wide infrastructure (1) streamlines data sharing and use between UC researchers and public health agencies; (2) sets priority research agendas that reflect the needs of the state’s diverse communities; and (3) fosters research collaboration and evidence translation. This partnership may serve as a guide for how academic and public health entities can jointly prioritize, conduct, and act upon policy-relevant research for current and emerging threats.