AUTHOR=Fang Honglian , Cui Feng , Zhao Ying , Qian Qian , Yong Angel , Lan Peipei , Huang Chuanying 

TITLE=Transforming Alzheimer’s disease nursing: integrating holistic care, innovative interventions, and evidence-based practices for enhanced patient outcomes

JOURNAL=Frontiers in Public Health

VOLUME=Volume 13 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2025.1624310

DOI=10.3389/fpubh.2025.1624310

ISSN=2296-2565

ABSTRACT=BackgroundAlzheimer’s disease (AD) represents a significant global healthcare challenge with increasing prevalence in aging populations. Traditional care models often focus primarily on symptom management with insufficient attention to holistic patient needs.ObjectivesTo evaluate the effectiveness of an integrated care approach combining holistic nursing interventions, innovative technologies, and evidence-based practices for enhanced patient outcomes in AD.MethodsA mixed-methods quasi-experimental study involving 248 AD patients across 9 healthcare facilities over 24 months. The intervention group (n = 126) received an integrated care approach while the control group (n = 122) received usual care. Outcomes were assessed using validated instruments at baseline and 6-month intervals.ResultsPatients receiving integrated care showed significantly improved cognitive stability (ADAS-Cog change: 4.2 ± 3.1 vs. 7.8 ± 3.6 points, p < 0.001), enhanced quality of life (QoL-AD improvement: 3.8 ± 2.4 vs. -1.2 ± 2.9 points, p < 0.001), and reduced behavioral symptoms (NPI reduction: 15.4 ± 10.2 vs. -6.8 ± 12.5 points, p < 0.001). Caregiver burden decreased significantly (ZBI reduction: 10.8 ± 7.4 vs. -6.2 ± 8.1 points, p < 0.001).ConclusionThe integrated care approach demonstrates significant benefits across multiple domains, supporting its implementation for improving AD patient and caregiver outcomes.