AUTHOR=Gassert Florian T. , Bast Henriette , Urban Theresa , Frank Manuela , Gassert Felix G. , Willer Konstantin , Schick Rafael C. , Renger Bernhard , Koehler Thomas , Karrer Alexandra , Sauter Andreas P. , Fingerle Alexander A. , Makowski Marcus R. , Pfeiffer Franz , Pfeiffer Daniela 

TITLE=Comparison of dark-field chest radiography and CT for the assessment of COVID-19 pneumonia

JOURNAL=Frontiers in Radiology

VOLUME=Volume 4 - 2024

YEAR=2025

URL=https://www.frontiersin.org/journals/radiology/articles/10.3389/fradi.2024.1487895

DOI=10.3389/fradi.2024.1487895

ISSN=2673-8740

ABSTRACT=BackgroundDark-field chest radiography allows the assessment of the structural integrity of the alveoli by exploiting the wave properties of x-rays.PurposeTo compare the qualitative and quantitative features of dark-field chest radiography in patients with COVID-19 pneumonia with conventional CT imaging.Materials and methodsIn this prospective study conducted from May 2020 to December 2020, patients aged at least 18 years who underwent chest CT for clinically suspected COVID-19 infection were screened for participation. Inclusion criteria were a CO-RADS score ≥4, the ability to consent to the procedure and to stand upright without help. Participants were examined with a clinical dark-field chest radiography prototype. For comparison, a healthy control cohort of 40 subjects was evaluated. Using Spearman's correlation coefficient, correlation was tested between dark-field coefficient and CT-based COVID-19 index and visual total CT score as well as between the visual total dark-field score and the visual total CT score.ResultsA total of 98 participants [mean age 58 ± 14 (standard deviation) years; 59 men] were studied. The areas of signal intensity reduction observed in dark-field images showed a strong correlation with infiltrates identified on CT scans. The dark-field coefficient had a negative correlation with both the quantitative CT-based COVID-19 index (r = −.34, p = .001) and the overall CT score used for visual grading of COVID-19 severity (r = −.44, p < .001). The total visual dark-field score for the presence of COVID-19 was positively correlated to the total CT score for visual COVID-19 severity grading (r = .85, p < .001).ConclusionCOVID-19 pneumonia-induced signal intensity losses in dark-field chest radiographs are consistent with CT-based findings, showing the technique's potential for COVID-19 assessment.