AUTHOR=Michailov Yulia , Friedler Shevach , Saar-Ryss Bozhena 

TITLE=First clinical pregnancy and delivery achieved after using a new 3D imaging technology for sperm selection: a case report

JOURNAL=Frontiers in Reproductive Health

VOLUME=Volume 7 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/reproductive-health/articles/10.3389/frph.2025.1559684

DOI=10.3389/frph.2025.1559684

ISSN=2673-3153

ABSTRACT=ObjectiveTo report a case of a patient who, after experiencing recurrent failed implantations, underwent a novel technological intervention—using the Q300 device—which successfully led to a pregnancy and delivery of a healthy baby.DesignCase report.SettingBarzilai University Medical Center.Patient (s)A 33-year-old woman with primary infertility experienced recurrent implantation failure (RIF), while her 32-year-old male partner was diagnosed with severe oligo-astheno-teratozoospermia (OTA) syndrome.InterventionUsing Q300 device for selection of the morphologically compliant sperm cells for intracytoplasmic sperm injection (ICSI).Main outcome measuresSuccessful pregnancy and delivery.ResultsA unique case of clinical pregnancy and delivery involving a couple facing RIF and severe OTA. In this case, a new technology for sperm selection was used. The semen sample was examined using the Q300 device to choose WHO2021-morphologically compliant sperm cells for micro-injection. The resulting embryos were developed and then frozen. Later, a frozen-thawed embryo transfer was performed during the following natural menstrual cycle, leading to successful pregnancy and delivery.ConclusionThe utilization of this new 3D imaging technology underscores the evolving landscape of reproductive medicine and the potential it holds for transforming outcomes in challenging cases. By documenting such cases, we contribute to the ongoing dialogue to refine assisted reproductive technology (ART) protocols and improve reproductive outcomes for individuals facing similar challenges.Trial registrationNCT06232720 https://clinicaltrials.gov/study/NCT06232720. Date of registration: 15 Feb 2023. Date of enrollment of the first subject: 20 August 2023.