AUTHOR=Yin Shanshan , Yang Wanjia , Lin Feiyun , Jia Mei , Feng Ying , Chen Yanhong , Bai Xiaoxia , Dong Yihan , Mao Shuduan , Hayat Kashif , Jin Xuejing 

TITLE=Polycystic ovary syndrome and organochlorine pesticides: exploring potential links and mechanisms

JOURNAL=Frontiers in Reproductive Health

VOLUME=Volume 7 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/reproductive-health/articles/10.3389/frph.2025.1563414

DOI=10.3389/frph.2025.1563414

ISSN=2673-3153

ABSTRACT=Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder among women, characterized by metabolic abnormalities and infertility. Despite its high prevalence, the etiology and pathogenesis of PCOS remain poorly understood. Emerging evidence suggests that persistent organic pollutants (POPs), known for their detrimental effects on the endocrine and reproductive systems, may play a role in the development and progression of PCOS. Among POPs, organochlorine pesticides (OCPs) are particularly widespread and pose significant health risks. This review examines the potential of OCPs as an environmental factor in the development and progression of PCOS. It highlights the mechanisms through which OCPs may disrupt the hypothalamic-pituitary-ovarian (HPO) axis and impair hormonal regulation, contributing to the onset and exacerbation of PCOS. Evidence links OCPs to insulin resistance, obesity, and type 2 diabetes mellitus. These disruptions may occur via pathways involving hypothyroidism or altered adrenal androgen secretion. While current evidence supports a plausible connection between OCP exposure and PCOS, significant gaps and inconsistencies in the data warrant further investigation. Elucidating the precise mechanisms underlying these associations is crucial for developing targeted prevention and intervention strategies.