AUTHOR=Davoudian Katharina , Nemtsov Lidia , Thompson Michael TITLE=Challenges in the application of biosensor technology in the clinical biochemistry laboratory JOURNAL=Frontiers in Sensors VOLUME=Volume 6 - 2025 YEAR=2025 URL=https://www.frontiersin.org/journals/sensors/articles/10.3389/fsens.2025.1641221 DOI=10.3389/fsens.2025.1641221 ISSN=2673-5067 ABSTRACT=A biosensor device involves the transduction of a surface-oriented biochemical interaction into an electrical signal. This structure offers the potential for obtaining highly specific signals for the assay of bioanalytical targets in a rapid and cost-effective manner. These devices drive a rapidly expanding global market with notable contributions to analysis of blood glucose levels and great potential in the field of personalized medicine. However, some reluctance remains in the application of biosensors in clinical biochemistry laboratories. This article explores these challenges in attempts to highlight opportunities for improvement.