REVIEW article

Front. Space Technol.

Sec. Space Exploration

Leveraging Artificial Intelligence for Autonomous Space Healthcare: An Overview of Approaches for Deep Space Exploration

  • 1. Katholieke Universiteit Leuven, Leuven, Belgium

  • 2. Loughborough University, Loughborough, United Kingdom

  • 3. Studiecentrum voor Kernenergie Onderzoekscentrum Mol, Mol, Belgium

  • 4. Universite catholique de Louvain, Louvain-la-Neuve, Belgium

  • 5. Aerospace Medical Association, Alexandria, United States

  • 6. Belgian Nuclear Research Centre (SCK CEN), Mol, Belgium

The final, formatted version of the article will be published soon.

Abstract

Introduction: Artificial intelligence (AI) is revolutionizing various domains and holds significant potential for space medicine. As astronauts venture deeper into space, ensuring crew health and safety with minimal reliance on Earth-based support becomes critical. Methods: A structured literature review was conducted using databases including PubMed, Scopus, and Web of Science. Keywords included 'artificial intelligence', 'space medicine', 'astronaut health', and 'autonomous healthcare'. Articles were selected based on relevance to AI applications in monitoring, diagnostics, imaging, and radiation exposure. Results: AI-based technologies can support predictive models, real-time monitoring vital signs, biofluid analysis and radiation dose assessment. AI can also assist in the acquisition and interpretation of medical images. Conclusion: AI has strong potential to support autonomous healthcare in deep-space missions by enabling continuous physiological monitoring, assisting in predictive diagnostics, and augmenting clinical decision-making. These capabilities could contribute to earlier detection of health alterations and more informed treatment strategies in environments where medical resources are constrained. However, rather than fully replacing telemedicine, AI is more realistically expected to complement it. As communication delays beyond low Earth orbit limit real-time interaction with Earth-based medical experts, AI-driven decision-support systems may help bridge this gap, while delayed telemedical input and human oversight will likely remain important components of medical care during exploration-class missions.

Summary

Keywords

artificial intelligence, Astronaut Autonomy, Autonomous Health Monitoring, Deep space missions, space medicine

Received

06 November 2025

Accepted

06 August 2026

Copyright

© 2026 Kerremans, Dobney, Miranda, Manon, Cinelli PhD FAsMA, Parisi and Baatout. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

*Correspondence: Sarah Baatout

Disclaimer

All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

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