AUTHOR=Inoue Mika , Kubota Atsushi , Takazawa Yuji , Nakagawara Kosuke , Ishige Kazuya , Suzuki Yoshio 

TITLE=5′-UMP inhibited muscle atrophy due to detraining: a randomized, double-blinded, placebo-controlled, parallel-group comparative study

JOURNAL=Frontiers in Sports and Active Living

VOLUME=Volume 6 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/sports-and-active-living/articles/10.3389/fspor.2024.1403215

DOI=10.3389/fspor.2024.1403215

ISSN=2624-9367

ABSTRACT=Purpose: A short period of disuse of 1-2 weeks due to factors such as illness or injury can lead to muscle atrophy, affecting both athletic performance and health. Recent research has shown that uridine 5′-monophosphate (5′-UMP) can counteract disuse-induced muscle atrophy by increasing PGC-1α expression and inhibiting atrogin-1 expression. However, the effect of 5′-UMP on disuse muscle atrophy in humans remains unknown. Therefore, the aimed of this study was to explore the effects of 5′-UMP supplementation during detraining on short-term disuse muscle atrophy in healthy men. Methods: Following a 6-week resistance training program on upper arm, healthy men were randomized to either a UMP group (n = 11) or a placebo group (n = 10), taking their respective supplements during the 2-week detraining period. Muscle thickness, an indicator of muscle hypertrophy and atrophy, was measured at 3 positions (MT50, MT60, and MT70) at baseline, 1 week, and 2 weeks after detraining. Results: Both groups showed a significant decrease in muscle thickness at MT70. The relative decrease was greater in the placebo group (2.4 ± 2.8%) than in the UMP group (0.0 ± 2.0%), significantly (p = 0.034) at 1 week. However, no significant difference was observed at MT50 and MT60. Conclusion: After the hypertrophy, 5′-UMP may prevent muscle atrophy due to the detraining within the first week.