https://www.frontiersin.org/journals/stroke RSS Feed for Frontiers in Stroke | New and Recent Articles en-us Frontiers Feed Generator,version:1 2026-04-17T07:41:02.549+00:00 60 https://www.frontiersin.org/articles/10.3389/fstro.2026.1755828 https://www.frontiersin.org/articles/10.3389/fstro.2026.1755828 2026-04-14T00:00:00Z Original Research Andrés GallardoPablo M. LavadosPablo Albiña-PalmarolaGabriel CavadaAndrés RoldánVerónica V. Olavarría 50 mL or CT perfusion core >70 mL, up to 150 mL). All patients received reperfusion therapy (intravenous thrombolysis, EVT, or both). Collateral status on baseline single-phase CTA was graded using the Tan scale (0–3); no patients had grade 3. The primary outcome was 90-day modified Rankin Scale (mRS); secondary outcome was NIHSS at discharge.ResultsFifty-four patients met inclusion criteria (Tan 0: n = 24; Tan 1: n = 14; Tan 2: n = 16). Baseline NIHSS, ASPECTS, and core volume were similar across groups. Patients without collaterals (Tan 0) had worse 90-day outcomes (median mRS 4 [IQR 3–6]) compared with those with Tan 1 (2 [IQR 1–3]) or Tan 2 (1 [IQR 1–2]) collaterals (both p < 0.001), whereas Tan 1 and Tan 2 did not differ significantly (p = 0.27). NIHSS at discharge showed a similar gradient. In proportional-odds logistic regression, each one-grade increase in collateral status was associated with lower odds of worse 90-day mRS (adjusted per-grade OR 0.32; 95% CI 0.15–0.68; p = 0.003).ConclusionIn early-treated large-core AIS, even simple CTA-based collateral assessment strongly predicts recovery. Patients with absent collaterals follow a distinctly poorer trajectory, while those with any collateral filling behave more favorably. Incorporating collateral status into routine evaluation may improve prognostic accuracy and support treatment decisions in this challenging subgroup.]]> https://www.frontiersin.org/articles/10.3389/fstro.2026.1805422 https://www.frontiersin.org/articles/10.3389/fstro.2026.1805422 2026-04-13T00:00:00Z Clinical Trial Shweta Jain VermaBhavya NandaParamdeep KaurArya Devi K. S.Deepti AroraAneesh DhasanP. N. SylajaDheeraj KhuranaVijaya PamidimukkalaBiman Kanti RayVivek NambiarSanjith AaronGaurav MittalAparna R. PaiSankar Prasad GorthiSomasundaram KumaraveluYerasu Muralidhar ReddySunil NarayanNomal Chandra BorahRupjyoti DasGirish Baburao KulkarniVikram HudedThomas MathewRohit BhatiaPawan Kumar OjhaJayanta RoyAnand Girish VaishnavArvind SharmaAbhishek PathakSanjeev Kumar BhoiSudhir SharmaSulena SulenaAralikatte Onkarappa SarojaNeetu RamrakhianiMadhusudhan Byadarahalli KempegowdaMahesh KateTina GeorgeIvy SebastianMeenakshi SharmaRupinder DhaliwalJeyaraj D. Pandian https://www.frontiersin.org/articles/10.3389/fstro.2026.1814085 https://www.frontiersin.org/articles/10.3389/fstro.2026.1814085 2026-04-13T00:00:00Z Original Research Mehari GebreyohannsSidarrth PrasadKim D. BarkerJoshua D. E. AmosErica M. JonesLindsay M. RiskeyDaiwai M. OlsonAsmiet K. TechanTy A. JohnsonNneka L. Ifejika 80% followed a standardized institutional protocol when making decisions for wake-up strokes. Additionally, 75.5% of hospitals ordered MRIs for these cases in the acute setting.ConclusionA coordinated, systems-level approach to wake-up stroke care that integrates a standardized protocol may be valuable in promoting workflow processes.]]> https://www.frontiersin.org/articles/10.3389/fstro.2026.1751659 https://www.frontiersin.org/articles/10.3389/fstro.2026.1751659 2026-03-31T00:00:00Z Study Protocol Shannon J. DohertyCecília N. PrudenteReema Adham HindsDavid PierceNavzer D. EngineerJohn CarrithersDiana HansenW. Brent Tarver https://www.frontiersin.org/articles/10.3389/fstro.2026.1780242 https://www.frontiersin.org/articles/10.3389/fstro.2026.1780242 2026-03-19T00:00:00Z Original Research Rich HolmesSuzanne AckerleyDawn GoodwinLouise A. Connell https://www.frontiersin.org/articles/10.3389/fstro.2026.1679668 https://www.frontiersin.org/articles/10.3389/fstro.2026.1679668 2026-03-18T00:00:00Z Original Research Krista SchendelIsabella SantaviccaTimothy J. HerronSandy J. LwiBrian C. CurranJas M. ChokJuliana Baldo https://www.frontiersin.org/articles/10.3389/fstro.2026.1738822 https://www.frontiersin.org/articles/10.3389/fstro.2026.1738822 2026-03-12T00:00:00Z Original Research Farya FakooriKarlon H. JohnsonHannah GardenerCarolina M. GutierrezNegar AsdaghiLauri BishopScott C. BrownIszet Campo-BustilloGillian Gordon PerueEmir VeledarHao YingLili ZhouJose G. RomanoTatjana RundekErika Marulanda https://www.frontiersin.org/articles/10.3389/fstro.2026.1731911 https://www.frontiersin.org/articles/10.3389/fstro.2026.1731911 2026-03-09T00:00:00Z Original Research Sofi AnderssonAnna DanielssonKatharina S. SunnerhagenMargit Alt Murphy https://www.frontiersin.org/articles/10.3389/fstro.2026.1684121 https://www.frontiersin.org/articles/10.3389/fstro.2026.1684121 2026-03-04T00:00:00Z Systematic Review Manabesh NathAstha RaiShubham MisraPradeep Kumar https://www.frontiersin.org/articles/10.3389/fstro.2026.1742758 https://www.frontiersin.org/articles/10.3389/fstro.2026.1742758 2026-02-17T00:00:00Z Brief Research Report Svetlana Politz GelevaLudwig D. Schelosky 5), and elevated CRP may serve as an early indicator of SaP and support timely FEES-based assessment.DiscussionEarly elevated CRP levels in dysphagic stroke patients are indicative of aspiration-related inflammation and may serve as a sensitive early biomarker for stroke-associated pneumonia. The combined assessment of dysphagia severity and CRP supports improved early risk stratification and preventive management.]]> https://www.frontiersin.org/articles/10.3389/fstro.2026.1751007 https://www.frontiersin.org/articles/10.3389/fstro.2026.1751007 2026-02-12T00:00:00Z Original Research Elochukwu IbekweRobert KassingerNicholas MannixJing PengArchana Hinduja https://www.frontiersin.org/articles/10.3389/fstro.2026.1731953 https://www.frontiersin.org/articles/10.3389/fstro.2026.1731953 2026-02-12T00:00:00Z Study Protocol Wirginia KrzyściakTadeusz Popiela https://www.frontiersin.org/articles/10.3389/fstro.2026.1736530 https://www.frontiersin.org/articles/10.3389/fstro.2026.1736530 2026-02-12T00:00:00Z Original Research Shara JohnsonSamantha MooreMuqtasida FatimaAdam McInnesHeather Foulds https://www.frontiersin.org/articles/10.3389/fstro.2026.1746652 https://www.frontiersin.org/articles/10.3389/fstro.2026.1746652 2026-02-10T00:00:00Z Original Research Devan PatelMelanie MartinezSupreeya A. SaengchoteKartik MotwaniWilliam S. DoddZahra Hasanpour SegherlouHaiyan XuKoji HosakaBrian L. Hoh https://www.frontiersin.org/articles/10.3389/fstro.2026.1706746 https://www.frontiersin.org/articles/10.3389/fstro.2026.1706746 2026-02-02T00:00:00Z Original Research Daniel Zhihao HongRehena SultanaNur Sarah Binte IbrahimHui Meng ChangDeidre Anne De Silva https://www.frontiersin.org/articles/10.3389/fstro.2025.1643570 https://www.frontiersin.org/articles/10.3389/fstro.2025.1643570 2026-01-23T00:00:00Z Original Research Anne SchwarzChristina K. HollLorie BrinkmanAndrea J. StehmanIsabel Cardoso FerreiraNina SoleimaniEden FarahmandMaeve SettleShivani SakthiIvy VoNatalie OlivaresMin-Keun SongSteven C. Cramer https://www.frontiersin.org/articles/10.3389/fstro.2025.1727719 https://www.frontiersin.org/articles/10.3389/fstro.2025.1727719 2026-01-21T00:00:00Z Original Research Kurt MoelggAnel KarisikLucie BuergiLukas SchererLuisa DelazerBenjamin DejakumSilvia FelicettiTheresa KoehlerJulian GrannaChristian BoehmeRaimund PechlanerTheresa ProckThomas ToellAxel BauerMichael SchreinlechnerDaniel PavlukMichael KnoflachStefan KiechlLukas Mayer-Suess https://www.frontiersin.org/articles/10.3389/fstro.2025.1719748 https://www.frontiersin.org/articles/10.3389/fstro.2025.1719748 2026-01-15T00:00:00Z Original Research Yacine BoudibaRobin GensAnissa OurtaniGaël De BackerKaat GuldolfFenne VandervorstSylvie De Raedt median 9 days), poor functional outcome (modified Rankin Scale >2), and mortality at 3 months after stroke onset.ResultsMultiple logistic regression analysis showed that PSD was a predictor of prolonged hospital stay [odds ratio (OR): 4.085, 95% confidence interval (CI): 2.445–6.824] and poor functional outcome [OR: 3.362, 95% CI: 1.851–6.107) at 3 months after stroke onset, even after adjustment for age, premorbid disability, National Institutes of Health Stroke Scale on admission, PSP, and PSU. PSD was no predictor of mortality after stroke.ConclusionPSD is a predictor of prolonged hospital stay and poor functional outcome at 3 months after ischemic stroke, independent of PSP and PSU.]]> https://www.frontiersin.org/articles/10.3389/fstro.2025.1676220 https://www.frontiersin.org/articles/10.3389/fstro.2025.1676220 2026-01-09T00:00:00Z Original Research Saeedur RahmanErik HendricksonJamie HendersonSamuel McGrathAyah MekhaimarKishen MathiJake HudsonRobert SargentBrian Clapp https://www.frontiersin.org/articles/10.3389/fstro.2025.1718355 https://www.frontiersin.org/articles/10.3389/fstro.2025.1718355 2026-01-07T00:00:00Z Original Research Rachel PearsonNancy K. HillsKellie BaconShelby K. SheltonRowena RoqueTatiana MorenoMaria KuchherzkiCarl SchultzTheodore W. HeymingChristine K. FoxHeather J. Fullerton