AUTHOR=Meng Chunyang , Peng Lei , Li Jinze , Li Yunxiang , Li Jinming , Wu Ji TITLE=Comparison Between Single-Use Flexible Ureteroscope and Reusable Flexible Ureteroscope for Upper Urinary Calculi: A Systematic Review and Meta-Analysis JOURNAL=Frontiers in Surgery VOLUME=Volume 8 - 2021 YEAR=2021 URL=https://www.frontiersin.org/journals/surgery/articles/10.3389/fsurg.2021.691170 DOI=10.3389/fsurg.2021.691170 ISSN=2296-875X ABSTRACT=Objective: This article explores the differences in the effectiveness and safety of the treatment of upper urinary calculi between single-use flexible ureteroscope (su-fURS) and reusable flexible ureteroscope (ru-fURS). Methods: We systematically searched PubMed, Embase, Cochrane Library, Scopus database and CNKI databases within a period from the date of database establishment to November 2020. Stata 16 was used for calculation and statistical analyses. Results: A total of 1020 patients were included in 7 studies. Statistical differences were only found in the Clavien–Dindo grade II postoperative complication (OR 0.47; 95% CI 0.23 to 0.98; P = 0.04). No significant statistical differences were observed in operative time (OT), estimated blood loss (EBL), length of hospital stay (LOS) and stone-free rate (SFR). Conclusions: Our meta-analysis results demonstrate that su-fURS, compared with ru-fURS, has similar effectiveness and better security for treating upper urinary calculi.