AUTHOR=Nie Xilin , Shang Jinbiao , Wang Wendong 

TITLE=TERT genetic polymorphism rs2736100 is associated with an aggressive manifestation of papillary thyroid carcinoma

JOURNAL=Frontiers in Surgery

VOLUME=Volume 9 - 2022

YEAR=2023

URL=https://www.frontiersin.org/journals/surgery/articles/10.3389/fsurg.2022.1019180

DOI=10.3389/fsurg.2022.1019180

ISSN=2296-875X

ABSTRACT=Objectives: The TERT rs2736100 genetic polymorphism was commonly found in human malignancies, indicated its key role in cancer cell transformation. The aim of this study was to investigate the effects of the functional TERT rs2736100 genetic polymorphism in papillary thyroid carcinoma (PTC) patients` outcomes. Materials and Methods: We had performed a retrospective study of the relationship betweenrs2736100and clinicopathological outcomes of PTC in 500 patients (378 female and 122 male) aged 43.8±11.4 years (rang 15-74 years) with median follow-up of 60 months (range, 1 to 455 months). Results: The TERT rs2736100 genetic polymorphism (TG/GG versus TT) were significantly associated with several high risk clinicopathological features such as tumor spread, extra-thyroidal extension, central/lateral lymph node metastases, stage T III or IV disease. However, in the Kaplan-Meier survival analyses, the rs2736100 mutation was unrelated to the overall disease-free survival with a log-rank p>0.05. In the Cox-regression analyses, the overall survival rate of recurrence/neo-metastasis was related with lager size of tumor, younger age and tumor spread, but unrelated with rs2736100 mutation. Conclusions and Significance: The TERT rs2736100 genetic polymorphism positive was more likely to manifest with aggressive clinicopathological characteristics but cannot worse prognosis much in PTC.