AUTHOR=Chen Liqiang , Feng Qiang , Wang Wenjuan , Liu Lanbo 

TITLE=Incidence and Related Factors for Low-Extremity Deep Vein Thrombosis in Breast Cancer Patients Who Underwent Surgical Resection: What Do We Know and What Should We Care

JOURNAL=Frontiers in Surgery

VOLUME=Volume 9 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/surgery/articles/10.3389/fsurg.2022.755671

DOI=10.3389/fsurg.2022.755671

ISSN=2296-875X

ABSTRACT=Malignancy, surgical resection and neoadjuvant and/or adjuvant chemotherapy increase the low-extremity deep vein thrombosis (LDVT) risk in breast cancer patients, bringing in great physical burdens, disabilities and worse survivals. However, LDVT in surgical breast cancer patients is scarcely reported. Therefore, this study aimed to evaluate the incidence and related factors for LDVT in these patients. Patients with breast cancer undergoing surgical resection were included. LDVT was examined on the day of discharge and one month after the discharge. A total of 491 eligible patients were included, among which 11 (2.2%) patients occurred LDVT. Besides, higher age, history of diabetes mellitus, advanced T and TNM stages, higher platelet count and shorter activated partial thromboplastin time (APTT) were correlated with increased LDVT incidence (all P<0.05). Additionally, higher age (P=0.004, OR (95%CI): 1.082 (1.023-1.144)), history of diabetes mellitus (P=0.003, OR (95%CI): 10.426 (2.219-48.986)) and higher platelet count (P=0.008, OR (95%CI): 1.017 (1.004-1.029)) were independent factors for increased LDVT incidence, while higher APTT (P=0.004, OR (95%CI): 0.636 (0.467-0.866)) was an independent factor for decreased LDVT incidence. Lastly, the risk prediction model involving age, history of diabetes mellitus, platelet count and APTT showed a good ability to predict LDVT occurrence (area under curve: 0.919, 95%CI: 0.869-0.968). In conclusion, the LDVT incidence is 2.2%, and its independent factors consist of age, history of diabetes mellitus, platelet count and APTT in breast cancer patients undergoing surgical resection, which provides evidence for the prevention and surveillance of LDVT in surgical breast cancer.