AUTHOR=Kim Seoung Hoon 

TITLE=Metachronous pancreatic cancer 18 years after resection of common bile duct cancer: A case report

JOURNAL=Frontiers in Surgery

VOLUME=Volume 9 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/surgery/articles/10.3389/fsurg.2022.851524

DOI=10.3389/fsurg.2022.851524

ISSN=2296-875X

ABSTRACT=We report an extremely rare case of metachronous double cancers of the bile duct and pancreas in a single patient that underwent successful curative resections consecutively. At the age of 57, a woman had undergone pylorus-preserving pancreaticoduodenectomy for the lesion that was pathologically diagnosed as moderately differentiated adenocarcinoma of distal common bile duct. Eighteen years later, a pancreatic mass was detected during a follow-up examination. Abdominal computed tomography showed an enhanced 2.3 cm lesion at the remnant pancreas body, which suggested a diagnosis of primary pancreatic cancer or metastasis. After admission and further work-up confirming no other lesions, completion total pancreatectomy was performed. The pathological diagnosis of the resected specimen was moderately-differentiated pancreatic ductal adenocarcinoma, and this case highlights the occurrence of metachronous double primary cancers developed in both distal bile duct and pancreas with an interval of 18 years. This is the first report on the metachronous primary cancers of the bile duct and pancreas within review of English literatures in the MEDLINE. This case serves as another data point in leading to guide that surgeons should be vigilant for the postoperative long-term surveillance of patients with pancreatobiliary cancer.