AUTHOR=Talybov Rustam , Beylerli Ozal , Mochalov Vadim , Prokopenko Alexey , Ilyasova Tatiana , Trofimova Tatiana , Sufianov Albert , Guang Yang 

TITLE=Multiparametric MR Imaging Features of Primary CNS Lymphomas

JOURNAL=Frontiers in Surgery

VOLUME=Volume 9 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/surgery/articles/10.3389/fsurg.2022.887249

DOI=10.3389/fsurg.2022.887249

ISSN=2296-875X

ABSTRACT=Objective: Our aim was to indicate the insufficient effectiveness of the MR / CT perfusion technique as a part of multiparametric imaging in the differential diagnosis of primary CNS lymphoma (PCNSL) and high-grade gliomas or metastatic lesions.
Materials and Methods: We described ten patients with primary CNS lymphoma presented high value of rCBV. Seven cases IHC-proved. Patients underwent CT perfusion imaging (Canon Aquilion One, Iomeron 400 mg – 50 ml) and DSC perfusion imaging (General Electric Discovery W750 3T, Gadovist 7.5 ml). Immunohistochemistry markers list includes: СD3, CD20, CD34, Ki-67, VEGF.
Results: Classic and atypical radiographic features of the PCNSL, diagnostic capabilities of the MR / CT perfusion technique were described. 
Conclusion: Our cases suggest perfusion imaging has not proven efficiency for reliable differential diagnosis in context of primary CNS lymphoma, high-grade glioma (grade 3-4 WHO 2016) and metastatic tumors.