AUTHOR=Ma Xinru , Zhou Shiyu , Xu Xiaoling , Du Qin 

TITLE=Copper-containing nanoparticles: Mechanism of antimicrobial effect and application in dentistry-a narrative review

JOURNAL=Frontiers in Surgery

VOLUME=Volume 9 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/surgery/articles/10.3389/fsurg.2022.905892

DOI=10.3389/fsurg.2022.905892

ISSN=2296-875X

ABSTRACT=The antimicrobial properties of copper have been known since ancient times. In recent years, with the emergence of antibiotic resistance and the increasing need for reducingto reduce antibiotics’ application, nanoparticles (NPs) with antimicrobial properties have drawn wide attention. Nanotechnology has been gradually used in all aspects of the health care system, including multiple areas of dentistry. Copper-containing NPs may be incorporated or coated on the surface of dental materials, so as to inhibit oral pathogenic microorganisms’ growth and  formation of biofilms. This review aims to detail copper-containing NPs’ antimicrobial mechanism,cytotoxic effect and inhibitory effect on oral pathogenic microorganisms. Moreover,  their application in dentistry is also discussed.