AUTHOR=Liu Baoyi , Li Ang , Xu Jingkai , Cui Yong 

TITLE=Single-Cell Transcriptional Analysis Deciphers the Inflammatory Response of Skin-Resident Stromal Cells

JOURNAL=Frontiers in Surgery

VOLUME=Volume 9 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/surgery/articles/10.3389/fsurg.2022.935107

DOI=10.3389/fsurg.2022.935107

ISSN=2296-875X

ABSTRACT=The skin is the outermost barrier of the body. It has developed a sophisticated system against the ever-changing environment. The application of single-cell technology has revolutionized dermatology research, and unraveled the changes and interactions across skin resident cells in healthy and inflamed skin. Single-cell technology has revealed the critical roles of stromal cells in inflammatory response and explained a series of plausible past findings concerning skin immunity. Here, we summarized the functional diversity of skin stromal cells defined by single-cell analysis and how they orchestrated events leading to inflammatory diseases, including atopic dermatitis, psoriasis, vitiligo, and systemic lupus erythematosus.