AUTHOR=Jiang Haote , Sun Mengxiao , Shao Rongrong , Su Shuyue , Zhang Yuyang 

TITLE=Calcium channel blocker and risk of postoperation lymphatic-related complications among gynecologic malignances

JOURNAL=Frontiers in Surgery

VOLUME=Volume 9 - 2022

YEAR=2023

URL=https://www.frontiersin.org/journals/surgery/articles/10.3389/fsurg.2022.939034

DOI=10.3389/fsurg.2022.939034

ISSN=2296-875X

ABSTRACT=Purpose: This study was performed to assess the association of calcium channel blocker (CCB) and other potential factors with postoperative lymphatic-related morbidity in patients with cervical cancer and endometrial carcinoma.
Methods: Patients diagnosed with cervical cancer or endometrial carcinoma with pelvic lymphadenectomy between January 2017 and January 2022 were enrolled. Postoperative lymphatic-related morbidity was evaluated by calculating the lymph cyst occurrence within 3 months after surgery and the duration of pelvic drainage. Univariate analyses evaluating the risk factors for lymphatic-related morbidity were performed. 
Results: Of a total of 251 patients, 52 patients were diagnosed as lymphatic cysts by B-ultrasound or computed tomography, and the duration of drainage from 110 patients exceeded the average number of days. The use of calcium channel blocker is a factor affecting the post-operation recovery. Univariable analysis revealed that hypertension, CCB and lymph node metastasis were independent predictors of postoperative complications.
Conclusions: This study demonstrated that CCB may be a factor which associated with incidence of post-operation lymph cyst, and CCB usage prolongs the duration of pelvic drainage.