AUTHOR=Berna Giorgio , De Grazia Alessia , Antoniazzi Elisa , Romeo Marco , Dell’Antonia Francesco , Lovero Stefano , Marchica Paolo , Rizzetto Christian , Burelli Paolo 

TITLE=Novel three-dimensional acellular dermal matrix for prepectoral breast reconstruction: First year in review with BRAXON®Fast

JOURNAL=Frontiers in Surgery

VOLUME=Volume 9 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/surgery/articles/10.3389/fsurg.2022.970053

DOI=10.3389/fsurg.2022.970053

ISSN=2296-875X

ABSTRACT=Implant-based breast reconstruction is gaining worldwide popularity as a standard tool in breast cancer treatment. As personalized medicine evolves, surgeons’ commitment aims at increasingly optimized reconstructive procedures to ensure highly biocompatible materials and enhanced aesthetic-functional results. Acellular dermal matrices (ADMs) are collagen-based materials that have greatly helped this purpose in the last twenty years, firstly improving submuscular techniques and ultimately making prepectoral implant placement possible thanks to their bioactive anti-fibrosis action. Currently available technologies have recently produced the first three-dimensional biological matrices for a time-saving complete wrapping of the synthetic prosthesis, thus creating a total biological interface on the implant with patient's tissues. Here we report our experience on the first 23 eligible patients who received 3DADM-assisted prepectoral reconstruction. On a total of 27 breasts, overall complication rate was 11.1%, including one minor seroma (3.7%), one case of necrosis (3.7%) and one implant removal due to infection. As new-generation devices, 3D ADMs showed an effective performance allowing to reduce overall exposure time for implant preparation and proved an optimal safety profile.