AUTHOR=Guo Yaxin , Huang QiFeng 

TITLE=Diagnosis and treatment of isolated rib Langerhans cell histiocytosis in an adult: A case report

JOURNAL=Frontiers in Surgery

VOLUME=Volume 10 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/surgery/articles/10.3389/fsurg.2023.1084137

DOI=10.3389/fsurg.2023.1084137

ISSN=2296-875X

ABSTRACT=Langerhans cell histiocytosis (LCH) was first proposed in 1987 to define the disorder characterized by proliferation of abnormal Langerhans cells. It is more likely to occur in children < 15 years of age. Single-site and single-system LCH of rib is rare in adults. We present a rare case of isolated rib LCH in a 61-year-old male patient and expound the diagnosis and treatment of the disease. A 61-year-old male patient presented with a 15-day history of dull pain in the left chest was admitted to our hospital. PET/CT image showed obvious osteolytic bone destruction and abnormal FDG uptake (maximum standardized uptake value: 14.5) in the right fifth rib with local soft tissue mass formation. The patient was eventually confirmed the diagnosis of LCH by immunohistochemistry stain and treated with rib surgery. A thorough review of the literature regarding diagnosis and treatment of LCH is presented in this study.