AUTHOR=Qin Tong-xin , Yao Yun-tai ,  the Evidence in Cardiovascular Anesthesia(EICA) Group 

TITLE=Vasoplegic syndrome in patients undergoing heart transplantation

JOURNAL=Frontiers in Surgery

VOLUME=Volume 10 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/surgery/articles/10.3389/fsurg.2023.1114438

DOI=10.3389/fsurg.2023.1114438

ISSN=2296-875X

ABSTRACT=Vasoplegic syndrome is a common life-threatening complication that increases early mortality in patients undergoing heart transplantation. The objective was to summarize the risk factors, onset time and treatment of vasoplegic syndrome in patients undergoing heart transplantation. PubMed, OVID, CNKI, VIP and WANFANG databases were searched with the terms “vasoplegic syndrome,” “vasoplegia,” “vasodilatory shock,” and “heart transplant*,” to identify relevant articles. Data regarding patient characteristics, vasoplegic syndrome manifestation, perioperative management, and clinical outcomes were extracted and analyzed. Nine articles, with 12 patients aging from 7-to 69 years-old, were included. Onset time of vasoplegic syndrome varied from intraoperatively to two weeks postoperatively, including nine (75%) intraoperatively, and all patients were insensitive to vasoactive agents. Methylene blue, angiotensin Ⅱ,  ascorbic acid and hydroxocobalamin have been used to treat refractory vasoplegic syndrome.