AUTHOR=Zhang Renjie , Liao Yiling , Yang Xiaoya , Tian Hengyu , Wu Shenfeng , Zeng Qingteng , He Qinghua , Zhang Ruikun , Wei Chunshan , Liu Jialin 

TITLE=Effect of lidocaine pumped through hepatic artery to relieve pain of hepatic artery infusion chemotherapy

JOURNAL=Frontiers in Surgery

VOLUME=Volume 11 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/surgery/articles/10.3389/fsurg.2024.1378307

DOI=10.3389/fsurg.2024.1378307

ISSN=2296-875X

ABSTRACT=Background
This study aims to explore the analgesic effect of lidocaine pumped administered through the hepatic artery used induring hepatic artery infusion chemotherapy (HAIC) for hepatocellular carcinoma (HCC).
Methods
A total of 45 HCC patients were randomly divided into a study group and a control group. Both groups were injected withreceived oxaliplatin (OXA) based FOLFOX protocol by via electronic infusion pump. The study group was continuously infused with 100 mg of lidocaine during HAIC, while 5% glucose solution was infused in the same way as described above. The cChanges of in vital signs, visual analogue score (VAS) and general comfort score (GCQ scale) were recorded before surgery (Time point 0), at the end of infusion (Time point 01), 1 hour after HAIC (Time point 02), 3 hours after HAIC (Time point 03) and 6 hours after HAIC (Time point 04). 

Results
At each point of time from Time point 0 through Time point 04, the differences in MAP, RR and SPO2 between the two groups were not statistically significant (P＞0.05). At each point of time from Time point 01 through Time point 04, the mean VAS scores in the study group were smaller and GCQ scores were higher than those in the control group, and the differences  were both statistically significant (P < 0.05). 

Conclusions 
Lidocaine infusion through the hepatic artery during HAIC effectively reduces intraoperative and postoperative pain and improves patient satisfaction with pain management, making it a valuable technique for clinical practice.